{"id":22206,"date":"2023-07-18T16:42:39","date_gmt":"2023-07-18T20:42:39","guid":{"rendered":"https:\/\/www.mesotheliomahope.com\/?page_id=22206"},"modified":"2025-12-15T15:19:26","modified_gmt":"2025-12-15T20:19:26","slug":"biomarkers-blood-tests","status":"publish","type":"page","link":"https:\/\/www.mesotheliomahope.com\/mesothelioma\/diagnosis\/biomarkers-blood-tests\/","title":{"rendered":"Mesothelioma Blood Tests and Biomarkers"},"content":{"rendered":"<h2>What Are Mesothelioma Blood Tests and Biomarkers?<\/h2>\n<p><strong>A blood test for mesothelioma<\/strong> is a medical test that analyzes a patient\u2019s blood sample to look for signs of certain biomarkers.<\/p>\n<p><strong>Mesothelioma biomarkers<\/strong> are molecules found in tissues, blood, and other bodily fluids that may be signs of mesothelioma. Biomarkers are sometimes called signature molecules or molecular markers.<\/p>\n<p>The presence of biomarkers does not necessarily mean you have mesothelioma. However, people with certain biomarkers are likely to have mesothelioma. Biomarkers can help doctors distinguish mesothelioma from other diseases when <a href=\"\/mesothelioma\/diagnosis\/\">diagnosing this cancer<\/a>.<\/p>\n<p>We can help get you or a family member in touch with mesothelioma specialists for an accurate diagnosis. Enroll in our <strong>Free Doctor Match<\/strong> program today to get started.<\/p>\n<div id=\"25223\" class=\"one-off-25223 widget widget_oscar-vque one-off\" data-vqueid=\"25223\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-25223{margin:60px auto}.one-off-25223 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:#e4f4f6;padding:20px 25px 200px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:360px;margin:0 auto}.one-off-25223 a::before{background:#0FAEBF;border-radius:50% 50% 0 0;content:'';position:absolute;bottom:0;height:19%;width:135%;left:-60px;z-index:0}.one-off-25223 .vque-content,.one-off-25223 .image-wrap{z-index:1;position:relative}.one-off-25223 .image-wrap{width:100%;position:absolute;left:-10px;bottom:-15px}.one-off-25223 .image-wrap img{position:absolute;bottom:0;width:100%;max-width:unset;left:0}.one-off-25223 .heading{font-size:27px;line-height:33px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-25223 ul{list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:26px}.one-off-25223 ul li{margin:0 0 15px;position:relative;padding-left:35px}.one-off-25223 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:21px;height:21px;display:block;position:absolute;left:0;top:4px;border-radius:50%;color:#fff;font-size:11px;text-align:center;line-height:21px}.one-off-25223 p{text-align:center}.one-off-25223 .button{padding:12px 16px;display:block}@media screen and (min-width:768px){.one-off-25223 a{max-width:620px;padding:30px 30px 35px;border-radius:0 0 4px 4px}.one-off-25223 a::before{border-radius:50%;height:155%;width:150%;right:-550px;left:unset;bottom:-295px}.one-off-25223 .heading{text-align:left;margin:2px 0 25px;max-width:unset;font-size:24px}.one-off-25223 ul{margin:-7px 0 30px;max-width:365px;line-height:23px}.one-off-25223 ul li::before{top:1px}.one-off-25223 .image-wrap{max-width:unset;position:absolute;right:-25px;bottom:-35px;margin:0 0 -2px;left:unset;width:380px}.one-off-25223 .image-wrap img{position:relative;bottom:0;left:0;width:380px}.one-off-25223 .button{display:inline-block;padding:14px 25px}.one-off-25223 p{text-align:left}}@media screen and (min-width:1150px){.one-off-25223 a{padding:30px}}<\/style><a href=\"\/get-matched\/\" title=\"Get Matched With a Mesothelioma Doctor\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Matched With a Mesothelioma Doctor Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Matched With a Mesothelioma Doctor<\/strong>\r\n        <ul>\r\n            <li>Find top specialists near you<\/li>\r\n            <li>Seek compensation for travel & care<\/li>\r\n            <li>Get medical guidance<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Matched Now\">Get Matched Now<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/07\/Doctors-ad.png\" alt=\"Get Matched With a Mesothelioma Doctor\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>Blood Tests for Mesothelioma<\/h2>\n<p>A mesothelioma blood test can show whether you have certain biomarkers that are common in mesothelioma patients. Imaging tests like <a href=\"\/mesothelioma\/diagnosis\/imaging-scans\/ct\/\">CT scans<\/a> can also detect irregular masses or tissue that could be cancerous. However, neither of these methods can confirm the presence of mesothelioma.<\/p>\n<p><strong>The only way to confirm a mesothelioma diagnosis is through a <a href=\"\/mesothelioma\/diagnosis\/biopsy\/\">biopsy<\/a>.<\/strong> This procedure involves removing a tissue or cell sample from your body so it can be tested in a lab. If the tissue is positive for mesothelioma cells, you have mesothelioma. Biopsies can also reveal tissue biomarkers such as calretinin and WT1.<\/p>\n<div class=\"did-you-know icon-bell\"><style type=\"text\/css\">.did-you-know{background:#F3F2F0;border-radius:10px;margin:40px 0;padding:20px 20px 20px 80px;position:relative}.did-you-know:before{position:absolute;left:20px;top:20px;width:45px;height:45px;background:#0FAEBF;border-radius:50px;color:#fff;text-align:center;line-height:45px;font-size:27px}.did-you-know .heading{font-size:24px;color:#100134;padding:10px 0;display:block;margin:0 0 5px}.did-you-know h2,.did-you-know .h2,.did-you-know h3,.did-you-know .h3{font-size:24px;line-height:1.14}@media screen and (min-width: 1024px){.did-you-know{padding:25px 25px 25px 90px}.did-you-know:before{left:25px;top:25px}.did-you-know .heading{padding:8px 0}.did-you-know h2,.did-you-know .h2,.did-you-know h3,.did-you-know .h3{font-size:24px;line-height:1.14}}<\/style><strong class=\"heading\">Did You Know?<\/strong><p>In November 2024, the Mayo Clinic announced it discovered a new method of detecting mesothelioma DNA with a <a href=\"\/blog\/innovative-mesothelioma-test-leads-to-earlier-diagnosis\/\">breakthrough blood test<\/a>.<\/p>\n<\/div>\n<h3 id=\"mesomark\">What Is the MESOMARK Test?<\/h3>\n<p>MESOMARK is a mesothelioma blood test that measures SMRPs in serum, a component of blood. <strong>SMRP stands for serum-measured soluble mesothelin-related peptide.<\/strong> SMRPs are created when pieces of mesothelin break off and enter the bloodstream. Mesothelioma cells usually make more mesothelin than healthy cells.<\/p>\n<p>Research has shown that people with mesothelioma have higher SMRP levels. Mesothelioma doctors can use the <a href=\"\/mesothelioma\/diagnosis\/biomarkers-blood-tests\/mesomark\/\">MESOMARK\u00a0 blood test<\/a> to monitor biomarkers after diagnosing them with this cancer. However, <strong>it is not yet approved to diagnose or detect mesothelioma.<\/strong><\/p>\n<p>Oncologists may perform other tests to help make a mesothelioma diagnosis, such as positron emission tomography (PET) scans and X-rays. Doctors should only use the MESOMARK blood test to test patients with the epithelial or biphasic <a href=\"\/mesothelioma\/cell-types\/\">mesothelioma cell types<\/a>. They should not use MESOMARK for patients with sarcomatoid mesothelioma cells.<\/p>\n<div class=\"callout-shortcode\"><style type=\"text\/css\">.callout-shortcode{background:#EDF8F9;border-radius:0 10px 10px 0;padding:20px 20px 20px 24px;margin:40px 0;max-width:860px;position:relative}.callout-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #EDF8F9 100%)}.callout-shortcode .callout-shortcode-heading{color:#100134;font-size:22px;display:block;margin:0 0 15px}.callout-shortcode:first-child{margin-top:0}.callout-shortcode:last-child{margin-bottom:0}.callout-shortcode .img-wrap{margin-bottom:20px}.callout-shortcode.hope>strong{padding-top:17px;padding-bottom:15px;padding-left:74px}.callout-shortcode.hope .img-wrap{left:22px;position:absolute;top:20px;width:59px}.callout-shortcode.hope .img-wrap:before{background:#fff url(\/wp-content\/uploads\/2024\/02\/mh-icon-65.png);background-position:center;background-repeat:no-repeat;background-size:70%;border-radius:30px;bottom:-10px;content:\"\";display:block;height:30px;position:absolute;right:-10px;width:30px}@media screen and (min-width: 768px){.callout-shortcode{padding:25px 25px 25px 34px}.callout-shortcode .callout-shortcode-heading{font-size:24px}.callout-shortcode .img-wrap{margin-bottom:0}.callout-shortcode.has-img{min-height:170px;padding-left:175px}.callout-shortcode.has-img .img-wrap{position:absolute;left:29px;top:25px;width:119px}.callout-shortcode.hope.has-img{padding-left:170px}.callout-shortcode.hope>strong{padding:0}.callout-shortcode.hope .img-wrap{width:109px}.callout-shortcode.hope .img-wrap:before{background-size:66%;bottom:-15px;height:42px;width:42px}}<\/style><div class=\"content\"><p>Learn more about the diagnosis process and get detailed information about this cancer in our <strong><a href=\"\/mesothelioma-guide\/\">Free Mesothelioma Guide<\/a><\/strong>, shipped to your door overnight.<\/p>\n<\/div><\/div>\n<h2>How Blood Tests for Mesothelioma Biomarkers Work<\/h2>\n<p><strong>Cancer care teams perform a blood test for mesothelioma by following these steps.<\/strong><\/p>\n<ol>\n<li><strong>Blood Sample Collection: <\/strong>First, your <a href=\"\/treatment\/doctors\/\">mesothelioma doctor<\/a> will collect a blood sample by extracting it from a vein. They will then send the sample to a lab for analysis.<\/li>\n<li><strong>Processing the Blood Sample:<\/strong> Lab technicians will process the blood sample by separating the cellular parts from the liquid serum.<\/li>\n<li><strong>Test Sample is Combined With Proteins:<\/strong>\u00a0The technicians will mix the test sample with unique antibodies or proteins.<\/li>\n<li><strong>Machine Measures Amount of Biomarkers: <\/strong>The technicians will use a machine and computer to determine the amount of biomarkers in the sample. High levels of mesothelioma biomarkers could mean the patient has mesothelioma or another malignant (cancerous) disease.<\/li>\n<\/ol>\n<h2>Is There a Blood Test for Asbestos Exposure?<\/h2>\n<p><strong>No,<\/strong> there is currently not an FDA-approved blood test for asbestos exposure, which is the only known cause of mesothelioma. Instead, doctors use <a href=\"\/mesothelioma\/diagnosis\/imaging-scans\/\">imaging scans<\/a> and biopsies to look for signs of asbestos-related cancer.<\/p>\n<p>While there is not an asbestos blood test, researchers have identified two potential biomarkers for asbestos exposure.<\/p>\n<p><strong>These biomarkers include:<\/strong><\/p>\n<ul>\n<li><strong>8-OHdG<\/strong> is a molecule linked to asbestos exposure. Cells produce 8-OHdG when they\u2019re damaged by asbestos fibers. People with a history of asbestos exposure have higher than average 8OHdG levels.<\/li>\n<li><strong>High mobility group box 1 (HMGB1)<\/strong> is a protein affected by asbestos exposure. Research shows that people exposed to asbestos have higher than normal levels of HMGB1.<\/li>\n<\/ul>\n<p>In the future, a blood test for <a href=\"\/asbestos\/exposure\/\">asbestos exposure<\/a> may help doctors diagnose mesothelioma earlier. Many mesothelioma patients may not remember when they were last exposed to asbestos since this cancer can take as long as 50 years to develop.<\/p>\n<h2 id=\"prognosis\">How Do Biomarkers Affect Mesothelioma Prognosis?<\/h2>\n<p>Biomarkers alone may not allow doctors to fully diagnose or detect mesothelioma. However, identifying mesothelioma biomarkers early can help diagnose mesothelioma sooner and help improve a <a href=\"\/mesothelioma\/prognosis\/\">patient\u2019s prognosis<\/a> (expected outcome, including life expectancy).<\/p>\n<p>The earlier patients receive a mesothelioma diagnosis and treatment, the better their prognosis. This is because aggressive treatments like surgery are generally more effective in early-stage mesothelioma before the cancer spreads.<\/p>\n<p>Unfortunately, certain <a href=\"\/treatment\/\">mesothelioma treatments<\/a> are less effective against advanced-stage cancer that has spread to other parts of the body.<\/p>\n<p>We can help you or a loved one connect with local mesothelioma specialists for an accurate diagnosis and treatment. Enroll in our <strong>Free Doctor Match service<\/strong> to get started.<\/p>\n<div id=\"25223\" class=\"one-off-25223 widget widget_oscar-vque one-off\" data-vqueid=\"25223\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-25223{margin:60px auto}.one-off-25223 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:#e4f4f6;padding:20px 25px 200px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:360px;margin:0 auto}.one-off-25223 a::before{background:#0FAEBF;border-radius:50% 50% 0 0;content:'';position:absolute;bottom:0;height:19%;width:135%;left:-60px;z-index:0}.one-off-25223 .vque-content,.one-off-25223 .image-wrap{z-index:1;position:relative}.one-off-25223 .image-wrap{width:100%;position:absolute;left:-10px;bottom:-15px}.one-off-25223 .image-wrap img{position:absolute;bottom:0;width:100%;max-width:unset;left:0}.one-off-25223 .heading{font-size:27px;line-height:33px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-25223 ul{list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:26px}.one-off-25223 ul li{margin:0 0 15px;position:relative;padding-left:35px}.one-off-25223 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:21px;height:21px;display:block;position:absolute;left:0;top:4px;border-radius:50%;color:#fff;font-size:11px;text-align:center;line-height:21px}.one-off-25223 p{text-align:center}.one-off-25223 .button{padding:12px 16px;display:block}@media screen and (min-width:768px){.one-off-25223 a{max-width:620px;padding:30px 30px 35px;border-radius:0 0 4px 4px}.one-off-25223 a::before{border-radius:50%;height:155%;width:150%;right:-550px;left:unset;bottom:-295px}.one-off-25223 .heading{text-align:left;margin:2px 0 25px;max-width:unset;font-size:24px}.one-off-25223 ul{margin:-7px 0 30px;max-width:365px;line-height:23px}.one-off-25223 ul li::before{top:1px}.one-off-25223 .image-wrap{max-width:unset;position:absolute;right:-25px;bottom:-35px;margin:0 0 -2px;left:unset;width:380px}.one-off-25223 .image-wrap img{position:relative;bottom:0;left:0;width:380px}.one-off-25223 .button{display:inline-block;padding:14px 25px}.one-off-25223 p{text-align:left}}@media screen and (min-width:1150px){.one-off-25223 a{padding:30px}}<\/style><a href=\"\/get-matched\/\" title=\"Get Matched With a Mesothelioma Doctor\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Matched With a Mesothelioma Doctor Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Matched With a Mesothelioma Doctor<\/strong>\r\n        <ul>\r\n            <li>Find top specialists near you<\/li>\r\n            <li>Seek compensation for travel & care<\/li>\r\n            <li>Get medical guidance<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Matched Now\">Get Matched Now<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/07\/Doctors-ad.png\" alt=\"Get Matched With a Mesothelioma Doctor\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>Signs of Reliable Mesothelioma Biomarkers<\/h2>\n<p>Researchers are continuing to look for reliable mesothelioma biomarkers and prognostic factors.<\/p>\n<p><strong>Generally speaking, mesothelioma biomarkers have the following qualities:<\/strong><\/p>\n<ul>\n<li>Absent in patients who do not have mesothelioma<\/li>\n<li>Located in an easily accessible and easy-to-measure body part or fluid, such as saliva or blood<\/li>\n<li>Present in patients with mesothelioma<\/li>\n<\/ul>\n<h2>Types of Mesothelioma Biomarkers<\/h2>\n<p>There are two main types of mesothelioma biomarkers: tissue biomarkers and non-tissue biomarkers.<\/p>\n<p>Learn more about these two biomarker types below.<\/p>\n<h3>Tissue Biomarkers<\/h3>\n<p>These are certain biomarkers that are found in samples within the body&#8217;s tissues and are usually linked to mesothelioma.<\/p>\n<p><strong>Examples of tissue biomarkers include:<\/strong><\/p>\n<ul>\n<li><strong>Calretinin<\/strong> is a protein that binds calcium that has an important part in many cellular processes. If you test positive for calretinin, there is a high chance you have mesothelioma. However, doctors will need to perform a biopsy to confirm your diagnosis.<\/li>\n<li><strong>Cytokeratin<\/strong> 5\/6 is a positive marker for malignant pleural mesothelioma. It is found in over 75% of patients. Doctors may use the presence of cytokeratin 5\/6 to distinguish <a href=\"\/mesothelioma\/mesothelioma-vs-lung-cancer\/\">distinguish pleural mesothelioma from lung cancer<\/a> and lung adenocarcinomas.<\/li>\n<li><strong>WT1<\/strong> is a gene that controls the Wilms tumor protein and is often found in higher levels in mesothelioma cells and other malignant cancers.<\/li>\n<\/ul>\n<h3>Non-Tissue Biomarkers<\/h3>\n<p>Not all biomarkers are tissue biomarkers. Some may or may not point to a mesothelioma diagnosis.<\/p>\n<p><strong>Examples of non-tissue biomarkers include:<\/strong><\/p>\n<ul>\n<li><strong>Fibulin-3<\/strong> is commonly found at high levels in <a href=\"\/mesothelioma\/pleural\/\">pleural mesothelioma<\/a> patients. Doctors may detect it in biopsy fluid or blood. Teams may use fibulin-3 to distinguish between mesothelioma and other conditions, including benign (non-cancerous) illnesses and other types of cancer.<\/li>\n<li><strong>Megakaryocyte potentiating factor (MPF)\/n-ERC<\/strong> is another type of protein. Testing has revealed that it is present in mesothelioma patients, but not in the blood of healthy volunteers. Research has suggested that MPF can help researchers distinguish between benign <a href=\"\/asbestos\/related-diseases\/\">asbestos-related illnesses<\/a> and cancers like mesothelioma.<\/li>\n<li><strong>Serum mesothelin<\/strong> is a blood protein biomarker and is currently considered the best blood protein biomarker of mesothelioma. It is normally found in the lining of major body organs (the peritoneum, pericardium, and pleura). However, the gene expression of serum mesothelin is abnormally high when mesothelioma is present.<\/li>\n<li><strong>SMRPs<\/strong> are broken bits of mesothelin. People with a history of asbestos exposure, including mesothelioma patients, have higher SMRP rates than those with no exposure.<\/li>\n<\/ul>\n<h2>Early Detection of Mesothelioma With Blood Testing<\/h2>\n<p>Studies have suggested that SMRP blood testing may result in an earlier diagnosis of mesothelioma.<\/p>\n<p>Specifically, the SMRP test has the potential to identify mesothelioma in high-risk individuals with histories of asbestos exposure. This includes people who have worked in asbestos-related industries, such as shipyards and construction workers.<\/p>\n<p>Past research has contributed to this theory. In a study published in <em>The Lancet Oncology<\/em> journal, <strong>researchers took multiple SMRP readings and found that people who developed mesothelioma had elevated SMRP levels.<\/strong><\/p>\n<p>More specifically, researchers discovered that people who later developed mesothelioma had elevated SMRP levels 1 to 5 years before they were diagnosed. The study also revealed that some asbestos-exposed people have normal SMRP levels throughout the study, and that none of these individuals developed mesothelioma at last follow-up.<\/p>\n<h2 id=\"research\">Research on Mesothelioma Biomarkers and Testing<\/h2>\n<p>Scientists are researching mesothelioma biomarkers in breath testing and CAR T-cell treatment through clinical trials. They have also identified additional potential biomarkers.<\/p>\n<p>Learn more about these efforts and the results of clinical trials below.<\/p>\n<h3>Breath Testing<\/h3>\n<p>Scientists have studied molecules in exhaled breath for potential use in diagnosing mesothelioma. If their efforts are fruitful, a breath test for mesothelioma can greatly improve the ease and speed of diagnosis. This technology is promising but requires more research.<\/p>\n<h3>Mesothelioma Biomarkers in CAR T-Cell Treatment<\/h3>\n<p>A study published in the journal <em>Cancer Discovery<\/em> revealed that biomarkers can be used to improve pleural malignant mesothelioma treatment.<\/p>\n<p><strong>In a <a href=\"\/treatment\/clinical-trials\/\">clinical trial<\/a>, researchers treated patients with a combination of two immunotherapies:<\/strong><\/p>\n<ul>\n<li><a href=\"\/treatment\/immunotherapy\/keytruda\/\"><strong>Pembrolizumab (Keytruda\u00ae)<\/strong><\/a> is a checkpoint inhibitor immunotherapy drug. It interferes with an immune checkpoint protein that may stop immune system cells from killing cancer cells. This drug encourages immune cells to attack tumors by blocking this checkpoint.<\/li>\n<li><a href=\"\/treatment\/immunotherapy\/car-t-cell-therapy\/\"><strong>Mesothelin-targeted CAR T-cell therapy<\/strong><\/a> involves taking a sample of the patient\u2019s immune cells and reprogramming them to kill mesothelioma cells by targeting mesothelin. These reprogrammed cells are called CAR T-cells.<\/li>\n<\/ul>\n<p>The patients who received combination <a href=\"\/treatment\/immunotherapy\/\">immunotherapy<\/a> had an <strong>overall survival (life expectancy) of 23.9 months.<\/strong> This is significantly higher than the median life expectancy of <strong>13 to 16 months<\/strong> for patients who undergo combination chemotherapy treatment with cisplatin and pemetrexed.<\/p>\n<p>The study results also showed a reduction in serum SMRP levels among the patients enrolled in the trial.<\/p>\n<div class=\"callout-shortcode\"><style type=\"text\/css\">.callout-shortcode{background:#EDF8F9;border-radius:0 10px 10px 0;padding:20px 20px 20px 24px;margin:40px 0;max-width:860px;position:relative}.callout-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #EDF8F9 100%)}.callout-shortcode .callout-shortcode-heading{color:#100134;font-size:22px;display:block;margin:0 0 15px}.callout-shortcode:first-child{margin-top:0}.callout-shortcode:last-child{margin-bottom:0}.callout-shortcode .img-wrap{margin-bottom:20px}.callout-shortcode.hope>strong{padding-top:17px;padding-bottom:15px;padding-left:74px}.callout-shortcode.hope .img-wrap{left:22px;position:absolute;top:20px;width:59px}.callout-shortcode.hope .img-wrap:before{background:#fff url(\/wp-content\/uploads\/2024\/02\/mh-icon-65.png);background-position:center;background-repeat:no-repeat;background-size:70%;border-radius:30px;bottom:-10px;content:\"\";display:block;height:30px;position:absolute;right:-10px;width:30px}@media screen and (min-width: 768px){.callout-shortcode{padding:25px 25px 25px 34px}.callout-shortcode .callout-shortcode-heading{font-size:24px}.callout-shortcode .img-wrap{margin-bottom:0}.callout-shortcode.has-img{min-height:170px;padding-left:175px}.callout-shortcode.has-img .img-wrap{position:absolute;left:29px;top:25px;width:119px}.callout-shortcode.hope.has-img{padding-left:170px}.callout-shortcode.hope>strong{padding:0}.callout-shortcode.hope .img-wrap{width:109px}.callout-shortcode.hope .img-wrap:before{background-size:66%;bottom:-15px;height:42px;width:42px}}<\/style><div class=\"content\"><p>If you\u2019ve been diagnosed with mesothelioma, our Patient Advocates can help you find clinical trials testing immunotherapy and other emerging treatments. Get started today by calling <a href=\"tel:+18666088933\" title=\"Click to call (866) 608-8933\" class=\"in-content-tel-link\" data-ce-category=\"Click to Call\" data-ce-label=\"(866) 608-8933\">(866) 608-8933<\/a>.<\/p>\n<\/div><\/div>\n<h3>Emerging Mesothelioma Biomarkers<\/h3>\n<p>Besides the ones mentioned above, researchers have found other potential biomarkers that may be detected by a mesothelioma blood test in the future.<\/p>\n<p><strong>Some of these emerging mesothelioma biomarkers include:<\/strong><\/p>\n<ul>\n<li><strong>Epidermal growth factor receptor (EGFR)<\/strong> is a protein that helps cells grow. EGFR mutations can make cells grow too much, leading to cancer. Higher levels of EGFR seem to lead to a poor prognosis.<\/li>\n<li><strong>Estrogen receptor beta or NR3A2 is a type of estrogen receptor.<\/strong> In one study, mesothelioma patients with higher estrogen receptor beta levels had higher <a href=\"\/mesothelioma\/prognosis\/survival-rate\/\">survival rates<\/a>.<\/li>\n<li><strong>Osteopontin<\/strong> is a protein produced in high quantities by some cancerous tumors. Colon cancer, breast cancer, and lung cancer cells produce a lot of osteopontin. More research must be done before osteopontin can be used as a diagnostic tool.<\/li>\n<\/ul>\n<p>A May 2025 study found that asbestos exposure causes specific changes in gene expression in people with pleural mesothelioma, turning some genes on and others off. These findings could help researchers develop better tools for early detection and more targeted treatments in the future.<\/p>\n<h2 id=\"help\">Get Help Confirming Your Mesothelioma Diagnosis<\/h2>\n<p>It\u2019s important to find a specialist immediately if you believe you have mesothelioma. A doctor may use a mesothelioma blood test alongside imaging scans and biopsies to provide an accurate diagnosis.<\/p>\n<p>If you have mesothelioma, your specialist will create a customized treatment plan to improve your prognosis and enhance your quality of life.<\/p>\n<p><a href=\"\/get-matched\/\">Use our Free Doctor Match<\/a> to get in touch with top mesothelioma doctors in your area.<\/p>\n<div class=\"faq-wrap\"><h2 class=\"faq-wrap-heading\">Mesothelioma Blood Test FAQs<\/h2><div class=\"faq\" data-faq=\"1\"><h3 class=\"faq-heading\">Does mesothelioma show up in blood tests?<\/h3><div><p>No, mesothelioma doesn\u2019t show up in routine blood work or standard lab testing.<\/p>\n<p>That said, specific blood tests may be used as part of the diagnostic process and to monitor the disease&#8217;s progression or response to treatment. <strong>An example of a mesothelioma blood test would be the soluble mesothelin-related peptide (SMRP) test.<\/strong><\/p>\n<p>Mesothelin is a protein that&#8217;s often overexpressed in mesothelioma cells, so the SMRP test measures the levels of this protein in blood. Elevated levels could indicate that the patient has mesothelioma.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"2\"><h3 class=\"faq-heading\">What are the markers for malignant mesothelioma?<\/h3><div><p>The most specific biomarkers for mesothelioma are <strong>serum mesothelin, calretinin, WT1, and cytokeratin 5\/6.<\/strong><\/p>\n<p>If you test positive for these markers, you have a high chance of having mesothelioma. However, doctors can only confirm a mesothelioma diagnosis through a biopsy.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"3\"><h3 class=\"faq-heading\">How do you prove mesothelioma?<\/h3><div><p><strong>A tissue biopsy<\/strong> is the only way to confirm mesothelioma. A biopsy is when doctors take a tissue or cell sample from a suspicious area and test it for mesothelioma cells.<\/p>\n<p>Other tests, including imaging scans and blood tests, may be used to narrow down a possible mesothelioma diagnosis before a biopsy.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"4\"><h3 class=\"faq-heading\">Is there an early test for mesothelioma?<\/h3><div><p><strong>Yes.<\/strong> It\u2019s sometimes possible to detect a case of mesothelioma early on before it has spread.<\/p>\n<p>Detecting this cancer at an early stage is hard as it takes 10-50 years for symptoms of mesothelioma to appear after asbestos exposure. However, early detection is crucial for better treatment outcomes.<\/p>\n<p>Doctors mainly use imaging tests and biopsies to diagnose mesothelioma. A mesothelioma blood test can assist in the process by showing if there are certain biomarkers present, which could mean you have cancer.<\/p>\n<p>Researchers are continuing to study emerging biomarkers that may help patients be diagnosed in the earlier stages of their cancer.<\/p>\n<\/div><\/div><script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\",\"@type\": \"FAQPage\",\"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Does mesothelioma show up in blood tests?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;No, mesothelioma doesn\u2019t show up in routine blood work or standard lab testing.&lt;\/p&gt;\n&lt;p&gt;That said, specific blood tests may be used as part of the diagnostic process and to monitor the disease&amp;#8217;s progression or response to treatment. &lt;strong&gt;An example of a mesothelioma blood test would be the soluble mesothelin-related peptide (SMRP) test.&lt;\/strong&gt;&lt;\/p&gt;\n&lt;p&gt;Mesothelin is a protein that&amp;#8217;s often overexpressed in mesothelioma cells, so the SMRP test measures the levels of this protein in blood. 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A mesothelioma blood test can assist in the process by showing if there are certain biomarkers present, which could mean you have cancer.&lt;\/p&gt;\n&lt;p&gt;Researchers are continuing to study emerging biomarkers that may help patients be diagnosed in the earlier stages of their cancer.&lt;\/p&gt;\n\"}}]}<\/script><style type=\"text\/css\">.faq-wrap{background:#E4F4F6;padding:20px 15px;margin:40px -15px}.faq-wrap:first-child{margin-top:0}.faq-wrap:last-child{margin-bottom:0}.faq-wrap .faq{background:#fff;padding:15px;border-radius:10px;box-shadow:0px 20px 20px rgba(0,0,0,0.03);margin:15px 0 0 0}.faq-wrap .faq:first-child{margin-top:0}.faq-wrap .faq .faq-heading{color:#100134;font-size:21px;margin-bottom:15px}.faq-wrap .faq p{margin-bottom:20px;line-height:1.5}.faq-wrap .faq p:last-child{margin-bottom:0}.faq-wrap .faq .learn-more{color:#248AFF;display:block;padding-right:17px;text-align:right;position:relative;line-height:1}.faq-wrap .faq .learn-more:visited{color:#248AFF}.faq-wrap .faq .learn-more:visited:hover,.faq-wrap .faq .learn-more:hover{color:#34d}.faq-wrap .faq .learn-more:after{font-family:\"mesohope\" !important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;content:\"\\e905\";position:absolute;right:0;top:3px}h2.faq-wrap-heading{margin-bottom:25px}@media screen and (min-width: 768px){.faq-wrap{padding:25px 15px}}@media screen and (min-width: 1024px){.faq-wrap{border-radius:10px;margin-left:auto;margin-right:auto;padding:25px}.faq-wrap .faq{padding:25px}.faq-heading{font-size:24px}}<\/style><\/div>\n","protected":false},"excerpt":{"rendered":"<p>What Are Mesothelioma Blood Tests and Biomarkers? A blood test for mesothelioma is a medical test that analyzes a patient\u2019s blood sample to look for signs of certain biomarkers. Mesothelioma biomarkers are molecules found in tissues, blood, and other bodily fluids that may be signs of mesothelioma. Biomarkers are sometimes called signature molecules or molecular&hellip;<\/p>\n","protected":false},"author":49,"featured_media":0,"parent":121,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-22206","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/22206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/comments?post=22206"}],"version-history":[{"count":0,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/22206\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/121"}],"wp:attachment":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media?parent=22206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}