{"id":23589,"date":"2024-02-23T11:05:16","date_gmt":"2024-02-23T16:05:16","guid":{"rendered":"https:\/\/www.mesotheliomahope.com\/?p=23589"},"modified":"2025-08-11T13:10:44","modified_gmt":"2025-08-11T17:10:44","slug":"breakthrough-pegargiminase-treatment","status":"publish","type":"post","link":"https:\/\/www.mesotheliomahope.com\/blog\/breakthrough-pegargiminase-treatment\/","title":{"rendered":"\u2018Breakthrough\u2019 Pegargiminase Treatment Quadruples Survival for Some Mesothelioma Patients"},"content":{"rendered":"<p>The new drug pegargiminase (ADI-PEG20) has been hailed as\u00a0<strong>a breakthrough in the treatment of <a href=\"\/mesothelioma\/\">mesothelioma<\/a><\/strong>, a rare cancer caused by asbestos exposure.<\/p>\n<p>The two-year ATOMIC-Meso trial explored the effectiveness of <a href=\"\/treatment\/chemotherapy\/pegargiminase\/\">pegargiminase<\/a>, a drug that restricts the body from producing a certain amino acid that fuels mesothelioma cancer growth.<\/p>\n<p><strong>After the third phase of the trial, ADI-PEG20 had successfully:<\/strong><\/p>\n<ul>\n<li>Helped patients live longer with minimal side effects<\/li>\n<li>Quadrupled 3-year <a href=\"\/mesothelioma\/prognosis\/survival-rate\/\">survival rates<\/a><\/li>\n<li>Stopped cancer progression for over 6 months<\/li>\n<\/ul>\n<p>These results move the drug closer to final approval by the U.S. Food and Drug Administration (FDA) as the first new mesothelioma chemotherapy treatment in decades.<\/p>\n<p>Download our <strong>Free Chemotherapy Guide<\/strong> to learn about the top cancer drugs for mesothelioma, what to expect, and how to manage side effects.<\/p>\n<div id=\"28840\" class=\"one-off-28840 widget widget_oscar-vque one-off\" data-vqueid=\"28840\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-28840{margin:60px auto;max-width:335px}.one-off-28840:first-child{margin-top:0}.one-off-28840:last-child{margin-bottom:0}.one-off-28840>a{background:#2F293D;display:block;padding:20px;padding-bottom:35px;border-radius:10px;color:#fff;text-decoration:none}.one-off-28840 img.mobile-only{margin:0 auto 20px;max-width:177px;width:100%}.one-off-28840 img:not(.mobile-only){display:none}.one-off-28840 .vque-content{font-size:16px;text-align:center}.one-off-28840 strong.heading{font-size:24px;display:block;margin:0}.one-off-28840 .subheading{font-size:14px}.one-off-28840 ul{font-size:16px;text-align:left;list-style:none;max-width:265px;line-height:1.4;margin:15px auto 25px}.one-off-28840 ul li{padding-left:28px;margin-bottom:15px}.one-off-28840 ul li:last-child{margin-bottom:0}.one-off-28840 ul li:before{font-family:\"mesohope\"!important;line-height:1;content:\"\\e904\";border:0;position:absolute;left:0;top:0;background:#0FAEBF;width:20px;height:20px;border-radius:20px;line-height:20px;text-align:center;font-size:12px}@media screen and (min-width:768px){.one-off-28840{max-width:620px}.one-off-28840>a{padding:0;background:linear-gradient(90.42deg,#2F293D 51.6%,#4A415F 109.35%)}.one-off-28840>a>div{display:block;display:flex;align-items:end;flex-wrap:wrap;position:relative}.one-off-28840 .vque-content{width:65%;padding:30px;text-align:left}.one-off-28840 img.mobile-only{display:none}.one-off-28840 img:not(.mobile-only){display:block;width:250px;margin-bottom:0;position:absolute;bottom:0;right:0}.one-off-28840 ul{max-width:none}.one-off-28840 ul li{margin-bottom:10px}}<\/style><a href=\"\/chemotherapy-guide\/\" title=\"Free Chemotherapy Guide\u2028for Mesothelioma Patients\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Free Chemotherapy Guide\u2028for Mesothelioma Patients Ad\"><div>\r\n<div>\r\n<div class=\"image-fade\">\r\n<img decoding=\"async\" src=\"\/wp-content\/uploads\/2025\/07\/thank-you-page-chemotherapy-img.png\" alt=\"Chemotherapy Guide Images\" class=\"mobile-only\">\r\n<img decoding=\"async\" src=\"\/wp-content\/uploads\/2025\/07\/chemo-guide-img.png\" alt=\"Chemotherapy Guide Images\">\r\n<\/div>\r\n<\/div>\r\n<div class=\"vque-content\">\r\n<strong class=\"heading\">Free Chemotherapy Guide\u2028for Mesothelioma Patients<\/strong>\r\n<span class=\"subheading\">Written by cancer nurses<\/span>\r\n<ul>\r\n<li>Top chemo drugs explained<\/li>\r\n<li>Preparing for your first session<\/li>\r\n<li>Managing side effects like\u2028nausea & fatigue<\/li>\r\n<\/ul>\r\n<p><strong class=\"button arrow\" title=\"Download It Now\">Download It Now<\/strong><\/p><\/div><\/div><\/a><\/div>\n<h2>Understanding ADI-PEG20 and the ATOMIC-Meso Trial<\/h2>\n<p>Dr. Peter Szlosarek of Queen Mary University of London has researched a protein called ASS1 for over 20 years. He was the first to discover that mesothelioma cells lack ASS1 and therefore can\u2019t produce their own arginine, an essential nutrient for cancer cell survival. As a result, mesothelioma must rely on arginine in the bloodstream to grow.<\/p>\n<p>Dr. Szlosarek sought to create a new therapy that could remove arginine from the blood and essentially <strong>starve cancer cells of their food supply<\/strong>. ADI-PEG20 is the culmination of Dr. Szlosarek\u2019s decades-long research.<\/p>\n<blockquote><p>\u201cIt\u2019s truly wonderful to see the research into the arginine starvation of cancer cells come to fruition. This discovery is something I have been driving from its earliest stages in the lab, with a new treatment, ADI-PEG20 (pegargiminase), <strong>now improving patient lives affected by mesothelioma<\/strong>.\u201d<\/p>\n<footer><cite><strong>&ndash; Dr. Peter Szlosarek<\/strong><\/cite><\/footer><\/blockquote><style type=\"text\/css\">blockquote{margin:40px 0;padding:0px 15px 0px 60px;position:relative;background-color:#fff}blockquote:before{content:\"\\e99d\";color:#fff;background-color:#0FAEBF;font-size:30px;font-family:\"mesohope\" !important;position:absolute;left:0;top:0;width:50px;height:50px;line-height:50px;text-align:center;border-radius:50%}blockquote p{margin:0}blockquote footer cite{font-size:inherit;line-height:26px;font-style:normal}@media screen and (min-width: 1024px){blockquote{padding:0px 90px 0px 85px}blockquote:before{font-size:35px;width:60px;height:60px;line-height:60px;left:0}}<\/style>\n<p>The purpose of the ATOMIC-Meso trial was to see how mesothelioma patients would respond to ADI-PEG20 when it was administered with <a href=\"\/treatment\/chemotherapy\/\">chemotherapy<\/a>.<\/p>\n<p>Half of the trial participants received weekly injections of ADI-PEG20, and the other half received a placebo. The patients who got ADI-PEG20 were also given a combination of the chemotherapy drugs pemetrexed and cisplatin or carboplatin every 3 weeks for 6 cycles.<\/p>\n<h3>About the Phase III ATOMIC-Meso Trial Participants<\/h3>\n<p><strong>Scientists describe ATOMIC-Meso as the largest trial of its kind, involving: <\/strong><\/p>\n<ul>\n<li>206 men and 43 women diagnosed with <a href=\"\/mesothelioma\/pleural\/\">pleural mesothelioma<\/a><\/li>\n<li>Researchers from 43 hospitals and medical institutions<\/li>\n<li>5 countries including the U.K., U.S., Australia, Italy, and Taiwan<\/li>\n<\/ul>\n<p>Each of these patients had nonepithelioid mesothelioma, a rare subtype of this cancer that is more resistant to treatment and spreads to other organs much more quickly than <a href=\"\/mesothelioma\/cell-types\/epithelioid\/\">epithelioid mesothelioma<\/a>. The average life expectancy for patients with this subtype is only 4 months.<\/p>\n<p>However, researchers were hopeful for improved survival in patients who took ADI-PEG20.<\/p>\n<h2>ADI-PEG20 Produces Encouraging Results<\/h2>\n<p>Researchers were pleased to find that the combination of pegargiminase and chemotherapy had positive results for patients.<\/p>\n<p><strong>The ATOMIC-Meso trial found patients who received ADI-PEG20:<\/strong><\/p>\n<ul>\n<li>Extended their <a href=\"\/mesothelioma\/prognosis\/life-expectancy\/\">life expectancy<\/a> by 1.6 months<\/li>\n<li>Were 4 times more likely to survive for 3 years following treatment<\/li>\n<li>Experienced 35% less risk of cancer progression<\/li>\n<\/ul>\n<p>The results of the ATOMIC-Meso trial indicate that pegargiminase is a promising <a href=\"\/treatment\/\">treatment<\/a> for pleural mesothelioma, the most common type of this cancer. The drug was also well tolerated, with most patients only experiencing mild side effects like nausea and fatigue.<\/p>\n<p>One mesothelioma patient enrolled in the <a href=\"\/treatment\/clinical-trials\/\">clinical trial<\/a> after being told he only had 4 months to live. He\u2019s now a <strong>5+ year survivor<\/strong>.<\/p>\n<blockquote><p>\u201cThis trial has changed the lives of people with mesothelioma, allowing us to live longer. I have five grandchildren and two great-grandchildren now \u2014 I wouldn\u2019t want to miss all that.&#8221;<\/p>\n<footer><cite><strong>&ndash; Patient enrolled in ATOMIC-Meso trial<\/strong><\/cite><\/footer><\/blockquote><style type=\"text\/css\">blockquote{margin:40px 0;padding:0px 15px 0px 60px;position:relative;background-color:#fff}blockquote:before{content:\"\\e99d\";color:#fff;background-color:#0FAEBF;font-size:30px;font-family:\"mesohope\" !important;position:absolute;left:0;top:0;width:50px;height:50px;line-height:50px;text-align:center;border-radius:50%}blockquote p{margin:0}blockquote footer cite{font-size:inherit;line-height:26px;font-style:normal}@media screen and (min-width: 1024px){blockquote{padding:0px 90px 0px 85px}blockquote:before{font-size:35px;width:60px;height:60px;line-height:60px;left:0}}<\/style>\n<p>Mesothelioma Hope can help you find clinical trials in your area so you can access the latest emerging treatments and increase your chances of survival. Call <strong><a href=\"tel:+18666088933\" title=\"Click to call (866) 608-8933\" class=\"in-content-tel-link\" data-ce-category=\"Click to Call\" data-ce-label=\"(866) 608-8933\">(866) 608-8933<\/a><\/strong> now to get started.<\/p>\n<h2>Get Help Finding Mesothelioma Treatment<\/h2>\n<p>In recent years, mesothelioma treatment advances have helped many patients far surpass their life expectancy. With this new drug, even more options may be available in the near future.<\/p>\n<p>If you or someone you love has been diagnosed with mesothelioma, our team can help you get the personalized care and support you need.<\/p>\n<p><strong>Our Patient Advocates at Mesothelioma Hope can help you:<\/strong><\/p>\n<ul>\n<li>Find a mesothelioma doctor near you<\/li>\n<li>Help you enroll in clinical trials for mesothelioma<\/li>\n<li>Understand your treatment options and potential side effects<\/li>\n<li>Connect you with peer mentors who have also faced mesothelioma<\/li>\n<\/ul>\n<p>Call a Patient Advocate now at <a href=\"tel:+18666088933\" title=\"Click to call (866) 608-8933\" class=\"in-content-tel-link\" data-ce-category=\"Click to Call\" data-ce-label=\"(866) 608-8933\">(866) 608-8933<\/a> or get the latest information on treating this cancer in our <a href=\"\/mesothelioma-guide\/\"><strong>Free Mesothelioma Guide<\/strong><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The new drug pegargiminase (ADI-PEG20) has been hailed as\u00a0a breakthrough in the treatment of mesothelioma, a rare cancer caused by asbestos exposure. The two-year ATOMIC-Meso trial explored the effectiveness of pegargiminase, a drug that restricts the body from producing a certain amino acid that fuels mesothelioma cancer growth. After the third phase of the trial,&hellip;<\/p>\n","protected":false},"author":35,"featured_media":23588,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[268],"tags":[],"class_list":["post-23589","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/posts\/23589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/users\/35"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/comments?post=23589"}],"version-history":[{"count":0,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/posts\/23589\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media\/23588"}],"wp:attachment":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media?parent=23589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/categories?post=23589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/tags?post=23589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}