{"id":24292,"date":"2024-05-16T10:55:35","date_gmt":"2024-05-16T14:55:35","guid":{"rendered":"https:\/\/www.mesotheliomahope.com\/?page_id=24292"},"modified":"2025-09-17T14:05:46","modified_gmt":"2025-09-17T18:05:46","slug":"ctla4","status":"publish","type":"page","link":"https:\/\/www.mesotheliomahope.com\/treatment\/immunotherapy\/ctla4\/","title":{"rendered":"CTLA-4"},"content":{"rendered":"<h2>What Is CTLA-4 Immunotherapy for Mesothelioma?<\/h2>\n<p>CTLA-4 inhibitors for mesothelioma, also called anti-CTLA-4 drugs or CTLA-4 antibodies, are a type of <a href=\"\/treatment\/immunotherapy\/\">immunotherapy<\/a> that may help you live longer.<\/p>\n<p>These inhibitors target a protein called cytotoxic T lymphocyte antigen-4 (CTLA-4) found on regulatory T cells, which your immune system makes to fight cancer.<\/p>\n<p>T cells use CTLA-4 to identify cancer cells to kill while sparing normal cells. However, <a href=\"\/mesothelioma\/\">mesothelioma<\/a> can hijack CTLA-4 to create an immunosuppressive effect. In other words, mesothelioma prevents the immune system from killing cancer cells. CTLA-4 inhibitors stop this from happening so more of the cancer can be destroyed.<\/p>\n<h2>Key Facts on CTLA-4 and Mesothelioma<\/h2>\n<ul>\n<li><strong>Types of mesothelioma treated:<\/strong> Pleural mesothelioma and peritoneal mesothelioma<\/li>\n<li><strong>How they\u2019re administered:<\/strong> Intravenous (IV) injection<\/li>\n<li><strong>When they\u2019re used:<\/strong> Typically with other mesothelioma treatments like surgery, chemotherapy, and different cancer immunotherapies<\/li>\n<li><strong>Most common side effects:<\/strong> Fever, nausea, vomiting, and loss of appetite<\/li>\n<\/ul>\n<p>Download our <strong>Free Immunotherapy Guide<\/strong> to learn more about CTLA-4 inhibitors and other immunotherapy drugs that could increase your life expectancy.<\/p>\n<div id=\"23756\" class=\"one-off-23756 widget widget_oscar-vque one-off\" data-vqueid=\"23756\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-23756{margin:60px auto}.one-off-23756 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:linear-gradient(90deg,#B1E5EA 0,#0FAEBF 100%);padding:20px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:350px;margin:0 auto}.one-off-23756 a::before{background:#EDF8F9;border-radius:0 0 50% 50%;content:'';position:absolute;top:0;height:87%;width:140%;left:-70px;z-index:0}.one-off-23756 .vque-content,.one-off-23756 .image-wrap{z-index:1;position:relative}.one-off-23756 .image-wrap{max-width:163px;display:block;margin:15px auto -21px}.one-off-23756 .heading{font-size:24px;line-height:28px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-23756 ul{max-width:160px;list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:27px}.one-off-23756 ul li{margin:0;position:relative;padding-left:28px}.one-off-23756 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:14px;height:14px;display:block;position:absolute;left:0;top:7px;border-radius:50%;color:#fff;font-size:7px;text-align:center;line-height:14px}.one-off-23756 p{text-align:center}.one-off-23756 .button{padding:12px 16px}@media screen and (min-width:768px){.one-off-23756 a{max-width:620px;padding:25px 50px 29px;border-radius:0 0 4px 4px}.one-off-23756 a::before{border-radius:0 0 100% 0;height:83%;width:70%;right:-70px;left:unset}.one-off-23756 a::after{background:#EDF8F9;border-radius:0;content:'';position:absolute;top:0;height:82%;width:50%;left:0;z-index:0}.one-off-23756 .heading{text-align:left;margin:5px 0 25px}.one-off-23756 ul{margin:-10px 0 22px}.one-off-23756 .image-wrap{max-width:unset;position:absolute;right:0;bottom:0;margin:0 0 -2px}.one-off-23756 p{text-align:left}}<\/style><a href=\"\/immunotherapy-guide\/\" title=\"Get Your Free Immunotherapy Guide\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Your Free Immunotherapy Guide Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Your Free Immunotherapy Guide<\/strong>\r\n        <ul>\r\n            <li>When it\u2019s used<\/li>\r\n            <li>Types of drugs<\/li>\r\n            <li>Side effects<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Your Free Guide\">Get Your Free Guide<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/03\/download-immunotherapy-guide.png\" alt=\"Free Immunotherapy Guide\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>How Does CTLA-4 for Mesothelioma Work?<\/h2>\n<p>CTLA-4 inhibitor drugs help your body\u2019s natural immune response to destroy mesothelioma cancer cells.<\/p>\n<p>They belong to a class of medications called <a href=\"\/treatment\/immunotherapy\/checkpoint-inhibitors\/\">immune checkpoint inhibitors<\/a>. These medications target specific checkpoint proteins like CTLA-4 found on T cells.<\/p>\n<div class=\"callout-shortcode\"><style type=\"text\/css\">.callout-shortcode{background:#EDF8F9;border-radius:0 10px 10px 0;padding:20px 20px 20px 24px;margin:40px 0;max-width:860px;position:relative}.callout-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #EDF8F9 100%)}.callout-shortcode .callout-shortcode-heading{color:#100134;font-size:22px;display:block;margin:0 0 15px}.callout-shortcode:first-child{margin-top:0}.callout-shortcode:last-child{margin-bottom:0}.callout-shortcode .img-wrap{margin-bottom:20px}.callout-shortcode.hope>strong{padding-top:17px;padding-bottom:15px;padding-left:74px}.callout-shortcode.hope .img-wrap{left:22px;position:absolute;top:20px;width:59px}.callout-shortcode.hope .img-wrap:before{background:#fff url(\/wp-content\/uploads\/2024\/02\/mh-icon-65.png);background-position:center;background-repeat:no-repeat;background-size:70%;border-radius:30px;bottom:-10px;content:\"\";display:block;height:30px;position:absolute;right:-10px;width:30px}@media screen and (min-width: 768px){.callout-shortcode{padding:25px 25px 25px 34px}.callout-shortcode .callout-shortcode-heading{font-size:24px}.callout-shortcode .img-wrap{margin-bottom:0}.callout-shortcode.has-img{min-height:170px;padding-left:175px}.callout-shortcode.has-img .img-wrap{position:absolute;left:29px;top:25px;width:119px}.callout-shortcode.hope.has-img{padding-left:170px}.callout-shortcode.hope>strong{padding:0}.callout-shortcode.hope .img-wrap{width:109px}.callout-shortcode.hope .img-wrap:before{background-size:66%;bottom:-15px;height:42px;width:42px}}<\/style><strong class=\"callout-shortcode-heading\">Function of Cytotoxic T Lymphocytes<\/strong><div class=\"content\"><p>Cytotoxic T lymphocyte is the medical term for a T cell that kills cancer. These cells use CTLA-4 to determine which cells should be killed.<\/p>\n<\/div><\/div>\n<p>However, mesothelioma cells make a protein called B7, which can bind to CTLA-4 on T cells. This makes T cells think mesothelioma cells don\u2019t need to be killed.<\/p>\n<p>CTLA-4 inhibitors prevent mesothelioma cells from binding, which releases the \u201cbrakes\u201d on your immune system and boosts T cell activation.<\/p>\n<h2>Types of CTLA-4 Inhibitors for Mesothelioma<\/h2>\n<p>As of 2025, ipilimumab (Yervoy) is the most commonly used CTLA-4 inhibitor for mesothelioma. Researchers are also studying another anti-CTLA-4 medication called tremelimumab (Imjudo).<\/p>\n<p>Learn about both types of mesothelioma CTLA-4 inhibitors below.<\/p>\n<h3>Ipilimumab (Yervoy\u00ae)<\/h3>\n<p>Yervoy is the only CTLA-4 inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat <a href=\"\/mesothelioma\/pleural\/\">malignant pleural mesothelioma<\/a> (which develops in the lining of the lungs).<\/p>\n<p>The FDA approved Yervoy in combination with nivolumab (Opdivo\u00ae), another immunotherapy that targets different proteins on T cells, in 2020 following the results of the CheckMate 743 clinical trial.<\/p>\n<div class=\"did-you-know icon-bell\"><style type=\"text\/css\">.did-you-know{background:#F3F2F0;border-radius:10px;margin:40px 0;padding:20px 20px 20px 80px;position:relative}.did-you-know:before{position:absolute;left:20px;top:20px;width:45px;height:45px;background:#0FAEBF;border-radius:50px;color:#fff;text-align:center;line-height:45px;font-size:27px}.did-you-know .heading{font-size:24px;color:#100134;padding:10px 0;display:block;margin:0 0 5px}.did-you-know h2,.did-you-know .h2,.did-you-know h3,.did-you-know .h3{font-size:24px;line-height:1.14}@media screen and (min-width: 1024px){.did-you-know{padding:25px 25px 25px 90px}.did-you-know:before{left:25px;top:25px}.did-you-know .heading{padding:8px 0}.did-you-know h2,.did-you-know .h2,.did-you-know h3,.did-you-know .h3{font-size:24px;line-height:1.14}}<\/style><strong class=\"heading\">Did You Know?<\/strong><p>This trial revealed that combining <a href=\"\/treatment\/immunotherapy\/opdivo-yervoy\/\">Opdivo and Yervoy<\/a> helped pleural mesothelioma patients live <strong>over 18 months<\/strong> on average when used as a first-line (initial) treatment. Their life expectancy was 4 months longer than the group that received the chemotherapy drugs pemetrexed and cisplatin.<\/p>\n<\/div>\n<p>A study from researchers at the MD Anderson Cancer Center found that Opdivo and Yervoy may also help patients with peritoneal mesothelioma (which develops in the abdominal lining).<\/p>\n<p>The patients in this study had an average life expectancy of <strong>19.1 months<\/strong> and a progression-free survival of <strong>5.5 months<\/strong> (where the cancer wasn\u2019t worsening). There was also a strong objective response rate (number of patients whose cancer shrank), with 25% of cases still responding to the treatment at the end of the study.<\/p>\n<div class=\"callout-shortcode\"><style type=\"text\/css\">.callout-shortcode{background:#EDF8F9;border-radius:0 10px 10px 0;padding:20px 20px 20px 24px;margin:40px 0;max-width:860px;position:relative}.callout-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #EDF8F9 100%)}.callout-shortcode .callout-shortcode-heading{color:#100134;font-size:22px;display:block;margin:0 0 15px}.callout-shortcode:first-child{margin-top:0}.callout-shortcode:last-child{margin-bottom:0}.callout-shortcode .img-wrap{margin-bottom:20px}.callout-shortcode.hope>strong{padding-top:17px;padding-bottom:15px;padding-left:74px}.callout-shortcode.hope .img-wrap{left:22px;position:absolute;top:20px;width:59px}.callout-shortcode.hope .img-wrap:before{background:#fff url(\/wp-content\/uploads\/2024\/02\/mh-icon-65.png);background-position:center;background-repeat:no-repeat;background-size:70%;border-radius:30px;bottom:-10px;content:\"\";display:block;height:30px;position:absolute;right:-10px;width:30px}@media screen and (min-width: 768px){.callout-shortcode{padding:25px 25px 25px 34px}.callout-shortcode .callout-shortcode-heading{font-size:24px}.callout-shortcode .img-wrap{margin-bottom:0}.callout-shortcode.has-img{min-height:170px;padding-left:175px}.callout-shortcode.has-img .img-wrap{position:absolute;left:29px;top:25px;width:119px}.callout-shortcode.hope.has-img{padding-left:170px}.callout-shortcode.hope>strong{padding:0}.callout-shortcode.hope .img-wrap{width:109px}.callout-shortcode.hope .img-wrap:before{background-size:66%;bottom:-15px;height:42px;width:42px}}<\/style><div class=\"content\"><p><strong>We can help you access Yervoy and Opdivo.<\/strong> <a href=\"\/about\/contact\/\">Contact us now<\/a> to connect with a Patient Advocate.<\/p>\n<\/div><\/div>\n<h3>Tremelimumab (Imjudo\u00ae)<\/h3>\n<p>Imjudo is currently available through clinical trials that test new mesothelioma treatments. Many of these trials have shown that <a href=\"\/treatment\/immunotherapy\/tremelimumab\/\">Imjudo<\/a> can extend patient survival.<\/p>\n<p>A 2023 phase II trial conducted by the Baylor College of Medicine found that surgery, Imjudo, and another immunotherapy called <a href=\"\/treatment\/immunotherapy\/durvalumab\/\">durvalumab (Imfinzi\u00ae)<\/a> helped pleural mesothelioma patients live longer than those who only received surgery and Imfinzi.<\/p>\n<p>In addition, the 2021 NIBIT-MESO-1 trial found that Imfinzi and Imjudo helped pleural and <a href=\"\/mesothelioma\/peritoneal\/\">peritoneal mesothelioma<\/a> patients who needed second-line treatment (used if initial therapies stop working). The patients had an average overall survival of <strong>16.6 months.<\/strong><\/p>\n<h2>CTLA-4 and Mesothelioma Treatment Plans<\/h2>\n<p>Anti-CTLA-4 immunotherapies can be used alone as a monotherapy. More commonly, though, doctors typically use them with other <a href=\"\/treatment\/\">mesothelioma treatments<\/a> in combination therapy to destroy as much of the cancer as possible.<\/p>\n<p><strong>CTLA-4 may be used with the following mesothelioma treatments:<\/strong><\/p>\n<ul>\n<li><strong>Chemotherapy:<\/strong> The in-progress phase III DREAM3R study is comparing the use of Opdivo, Yervoy, and chemotherapy to Imfinzi and chemotherapy in treating pleural mesothelioma.<\/li>\n<li><strong>Other immunotherapy drugs:<\/strong> Doctors can combine multiple immunotherapies to improve survival.<\/li>\n<li><strong>Surgery:<\/strong> In the previously mentioned Baylor College of Medicine study, patients received surgery after getting Imjudo to shrink solid tumors.<\/li>\n<\/ul>\n<p>Get our <strong>Free Immunotherapy Guide<\/strong> to learn more about CTLA-4 inhibitors and how they may help as part of your larger mesothelioma treatment plan.<\/p>\n<div id=\"23756\" class=\"one-off-23756 widget widget_oscar-vque one-off\" data-vqueid=\"23756\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-23756{margin:60px auto}.one-off-23756 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:linear-gradient(90deg,#B1E5EA 0,#0FAEBF 100%);padding:20px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:350px;margin:0 auto}.one-off-23756 a::before{background:#EDF8F9;border-radius:0 0 50% 50%;content:'';position:absolute;top:0;height:87%;width:140%;left:-70px;z-index:0}.one-off-23756 .vque-content,.one-off-23756 .image-wrap{z-index:1;position:relative}.one-off-23756 .image-wrap{max-width:163px;display:block;margin:15px auto -21px}.one-off-23756 .heading{font-size:24px;line-height:28px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-23756 ul{max-width:160px;list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:27px}.one-off-23756 ul li{margin:0;position:relative;padding-left:28px}.one-off-23756 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:14px;height:14px;display:block;position:absolute;left:0;top:7px;border-radius:50%;color:#fff;font-size:7px;text-align:center;line-height:14px}.one-off-23756 p{text-align:center}.one-off-23756 .button{padding:12px 16px}@media screen and (min-width:768px){.one-off-23756 a{max-width:620px;padding:25px 50px 29px;border-radius:0 0 4px 4px}.one-off-23756 a::before{border-radius:0 0 100% 0;height:83%;width:70%;right:-70px;left:unset}.one-off-23756 a::after{background:#EDF8F9;border-radius:0;content:'';position:absolute;top:0;height:82%;width:50%;left:0;z-index:0}.one-off-23756 .heading{text-align:left;margin:5px 0 25px}.one-off-23756 ul{margin:-10px 0 22px}.one-off-23756 .image-wrap{max-width:unset;position:absolute;right:0;bottom:0;margin:0 0 -2px}.one-off-23756 p{text-align:left}}<\/style><a href=\"\/immunotherapy-guide\/\" title=\"Get Your Free Immunotherapy Guide\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Your Free Immunotherapy Guide Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Your Free Immunotherapy Guide<\/strong>\r\n        <ul>\r\n            <li>When it\u2019s used<\/li>\r\n            <li>Types of drugs<\/li>\r\n            <li>Side effects<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Your Free Guide\">Get Your Free Guide<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/03\/download-immunotherapy-guide.png\" alt=\"Free Immunotherapy Guide\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>Side Effects of CTLA-4 Inhibitors for Mesothelioma<\/h2>\n<p>You may develop side effects while receiving CTLA-4 inhibitors, since they turn off the T cell\u2019s ability to distinguish between healthy cells and cancerous ones.<\/p>\n<p><strong>Common side effects of mesothelioma CTLA-4 inhibitors include:<\/strong><\/p>\n<\/p>\n<ul class='columns-2'>\n<li>Black or bloody stools<\/li>\n<li>Coughing<\/li>\n<li>Diarrhea<\/li>\n<li>Fever<\/li>\n<li>Headaches<\/li>\n<li>Itchy skin or rash<\/li>\n<li>Loss of appetite<\/li>\n<li>Nausea<\/li>\n<li>Pain in the legs, arms, or bones<\/li>\n<li>Severe cramping or stomach pain<\/li>\n<li>Sneezing<\/li>\n<li>Vomiting<\/li>\n<\/ul>\n<p>\n<p>In some cases, more serious long-term symptoms may develop, such as arthritis, hepatitis (liver inflammation), and neuropathy (numbness and tingling in limbs).<\/p>\n<p>Your mesothelioma doctor can explain these in more detail and prescribe medications to address any pain, nausea, or other side effects.<\/p>\n<h2>What to Expect During CTLA-4 Treatment Sessions<\/h2>\n<p>Mesothelioma CTLA-4 treatment sessions may vary slightly depending on the hospital or cancer center, but below is a general overview of what to expect.<\/p>\n<h3>1. Receive CTLA-4 Infusions<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-24310 size-medium\" src=\"https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2024\/05\/IV-injection-300x200.jpg\" alt=\"A patient receives a CTLA-4 infusion through an IV\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2024\/05\/IV-injection-300x200.jpg 300w, https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2024\/05\/IV-injection-150x100.jpg 150w, https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2024\/05\/IV-injection.jpg 724w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>You will receive a CTLA-4 medication through an IV drip into your bloodstream every 3-6 weeks. Each infusion takes between 30-90 minutes.<\/p>\n<p>If you\u2019re getting multiple treatments through an IV, such as different immunotherapy drugs or chemotherapy, your doctors will tell you which treatments you\u2019re receiving and when.<\/p>\n<h3>2. Monitor CTLA-4 and Mesothelioma Response<\/h3>\n<p>Your doctors will closely monitor how your mesothelioma tumors respond to CTLA-4 antibodies and any other treatments you receive. They\u2019ll also promptly address side effects or toxicity (harm from a medication).<\/p>\n<h3>3. Recover and Adjust Mesothelioma Treatment Plan<\/h3>\n<p>Following CTLA-4 treatments, your cancer care team will conduct a follow-up medical review to see how your cancer has responded. Hopefully, the mesothelioma tumors will have shrunk and your symptoms will start to lessen.<\/p>\n<p>If your cancer doesn\u2019t respond to CTLA-4 inhibitors or starts to grow back, your doctors can recommend other treatments that may improve your <a href=\"\/mesothelioma\/prognosis\/life-expectancy\/\">life expectancy<\/a>.<\/p>\n<h2>Clinical Trials Studying CTLA-4 and Mesothelioma<\/h2>\n<p>Besides those mentioned above, many other <a href=\"\/treatment\/clinical-trials\/\">mesothelioma clinical trials<\/a> are looking into how CTLA-4 immunotherapies can help patients with this cancer.<\/p>\n<p><strong>Trials studying CTLA-4 and mesothelioma include:<\/strong><\/p>\n<ul>\n<li><strong>Imjudo, Imfinzi, and Chemotherapy:<\/strong> This Baylor College of Medicine trial is studying whether combining chemotherapy with Imjudo and Imfinzi before surgery helps patients live longer than immunotherapy alone.<\/li>\n<li><strong>Opdivo, Yervoy, and Surgery:<\/strong> Researchers at <a href=\"\/cancer-centers\/sidney-kimmel-comprehensive-cancer-center-at-johns-hopkins\/\">Sidney Kimmel Comprehensive Cancer Center<\/a> are investigating whether Opdivo with or without Yervoy given prior to surgery will improve overall survival.<\/li>\n<li><strong>Oral 7HP349 (Alintegimod), Opdivo, and Yervoy:<\/strong> Patients with mesothelioma and other cancers will receive an experimental drug called Alintegimod, followed by Yervoy and then Opdivo.<\/li>\n<\/ul>\n<p>Use our <strong>Free Doctor Match<\/strong> to find specialists who can help you determine if you\u2019re a good fit for clinical trials on CTLA-4 and mesothelioma.<\/p>\n<div id=\"25223\" class=\"one-off-25223 widget widget_oscar-vque one-off\" data-vqueid=\"25223\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-25223{margin:60px auto}.one-off-25223 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:#e4f4f6;padding:20px 25px 200px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:360px;margin:0 auto}.one-off-25223 a::before{background:#0FAEBF;border-radius:50% 50% 0 0;content:'';position:absolute;bottom:0;height:19%;width:135%;left:-60px;z-index:0}.one-off-25223 .vque-content,.one-off-25223 .image-wrap{z-index:1;position:relative}.one-off-25223 .image-wrap{width:100%;position:absolute;left:-10px;bottom:-15px}.one-off-25223 .image-wrap img{position:absolute;bottom:0;width:100%;max-width:unset;left:0}.one-off-25223 .heading{font-size:27px;line-height:33px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-25223 ul{list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:26px}.one-off-25223 ul li{margin:0 0 15px;position:relative;padding-left:35px}.one-off-25223 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:21px;height:21px;display:block;position:absolute;left:0;top:4px;border-radius:50%;color:#fff;font-size:11px;text-align:center;line-height:21px}.one-off-25223 p{text-align:center}.one-off-25223 .button{padding:12px 16px;display:block}@media screen and (min-width:768px){.one-off-25223 a{max-width:620px;padding:30px 30px 35px;border-radius:0 0 4px 4px}.one-off-25223 a::before{border-radius:50%;height:155%;width:150%;right:-550px;left:unset;bottom:-295px}.one-off-25223 .heading{text-align:left;margin:2px 0 25px;max-width:unset;font-size:24px}.one-off-25223 ul{margin:-7px 0 30px;max-width:365px;line-height:23px}.one-off-25223 ul li::before{top:1px}.one-off-25223 .image-wrap{max-width:unset;position:absolute;right:-25px;bottom:-35px;margin:0 0 -2px;left:unset;width:380px}.one-off-25223 .image-wrap img{position:relative;bottom:0;left:0;width:380px}.one-off-25223 .button{display:inline-block;padding:14px 25px}.one-off-25223 p{text-align:left}}@media screen and (min-width:1150px){.one-off-25223 a{padding:30px}}<\/style><a href=\"\/get-matched\/\" title=\"Get Matched With a Mesothelioma Doctor\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Matched With a Mesothelioma Doctor Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Matched With a Mesothelioma Doctor<\/strong>\r\n        <ul>\r\n            <li>Find top specialists near you<\/li>\r\n            <li>Seek compensation for travel & care<\/li>\r\n            <li>Get medical guidance<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Matched Now\">Get Matched Now<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/07\/Doctors-ad.png\" alt=\"Get Matched With a Mesothelioma Doctor\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>How Much Does CTLA-4 Mesothelioma Treatment Cost?<\/h2>\n<p>The cost of mesothelioma CTLA-4 inhibitors depends on which ones you receive.<\/p>\n<p><strong>Here is a breakdown of CTLA-4 costs by type:<\/strong><\/p>\n<ul>\n<li><strong>Imjudo.<\/strong> This mesothelioma CTLA-4 medication is only available in clinical trials, <strong>which cost nothing to join<\/strong>. However, you must meet the criteria outlined in the study in order to receive Imjudo.<\/li>\n<li><strong>Yervoy.<\/strong> While Yervoy is more easily available than Imjudo, you\u2019ll need to pay out of pocket or use insurance to help cover the cost. According to Bristol Myers Squibb, a single Yervoy and Opdivo infusion costs <strong>$28,292<\/strong>. However, you may be able to access <a href=\"\/resources\/financial\/\">financial assistance<\/a> that can help pay for your treatment.<\/li>\n<\/ul>\n<div class=\"callout-shortcode\"><style type=\"text\/css\">.callout-shortcode{background:#EDF8F9;border-radius:0 10px 10px 0;padding:20px 20px 20px 24px;margin:40px 0;max-width:860px;position:relative}.callout-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #EDF8F9 100%)}.callout-shortcode .callout-shortcode-heading{color:#100134;font-size:22px;display:block;margin:0 0 15px}.callout-shortcode:first-child{margin-top:0}.callout-shortcode:last-child{margin-bottom:0}.callout-shortcode .img-wrap{margin-bottom:20px}.callout-shortcode.hope>strong{padding-top:17px;padding-bottom:15px;padding-left:74px}.callout-shortcode.hope .img-wrap{left:22px;position:absolute;top:20px;width:59px}.callout-shortcode.hope .img-wrap:before{background:#fff url(\/wp-content\/uploads\/2024\/02\/mh-icon-65.png);background-position:center;background-repeat:no-repeat;background-size:70%;border-radius:30px;bottom:-10px;content:\"\";display:block;height:30px;position:absolute;right:-10px;width:30px}@media screen and (min-width: 768px){.callout-shortcode{padding:25px 25px 25px 34px}.callout-shortcode .callout-shortcode-heading{font-size:24px}.callout-shortcode .img-wrap{margin-bottom:0}.callout-shortcode.has-img{min-height:170px;padding-left:175px}.callout-shortcode.has-img .img-wrap{position:absolute;left:29px;top:25px;width:119px}.callout-shortcode.hope.has-img{padding-left:170px}.callout-shortcode.hope>strong{padding:0}.callout-shortcode.hope .img-wrap{width:109px}.callout-shortcode.hope .img-wrap:before{background-size:66%;bottom:-15px;height:42px;width:42px}}<\/style><div class=\"content\"><p>Call our team at <a href=\"tel:+18666088933\" title=\"Click to call (866) 608-8933\" class=\"in-content-tel-link\" data-ce-category=\"Click to Call\" data-ce-label=\"(866) 608-8933\">(866) 608-8933<\/a> now to get help pursuing financial assistance for mesothelioma.<\/p>\n<\/div><\/div>\n<h2>Get Help Accessing CTLA-4 Inhibitors for Mesothelioma<\/h2>\n<p>CTLA-4 inhibitors like Yervoy and Imjudo have helped many other mesothelioma patients live longer, giving them precious time with family and friends. These immunotherapy medications could help you or a loved one as well.<\/p>\n<p>Yervoy is already widely available for many pleural mesothelioma patients, and Imjudo continues to show encouraging results in ongoing trials. Both medications have given hope to those facing a mesothelioma diagnosis.<\/p>\n<p>Use our <strong><a href=\"\/get-matched\/\">Free Doctor Match service<\/a><\/strong> to connect with mesothelioma specialists near you who are experienced with CTLA-4 drugs and other immunotherapies.<\/p>\n<div class=\"faq-wrap\"><h2 class=\"faq-wrap-heading\">CTLA-4 and Mesothelioma FAQs<\/h2><div class=\"faq\" data-faq=\"1\"><h3 class=\"faq-heading\">What is the function of CTLA-4 in mesothelioma cancer patients?<\/h3><div><p>Mesothelioma cells use proteins that they create to bind to a protein called CTLA-4 on T cells. This binding tells the T cells not to kill the cancer, allowing it to spread.<\/p>\n<p>Mesothelioma CTLA-4 inhibitors prevent mesothelioma cells from binding so the T cells can destroy them.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"2\"><h3 class=\"faq-heading\">What is the new immunotherapy for mesothelioma?<\/h3><div><p><strong>Tremelimumab (Imjudo\u00ae) is a new immunotherapy for mesothelioma.<\/strong> Imjudo blocks the CTLA-4 protein on T cells so they can more easily kill cancer, creating what is known as an antitumor response.<\/p>\n<p>Recent studies like the NIBIT-MESO-1 trial show that Imjudo can help both pleural and peritoneal mesothelioma patients live longer. Doctors continue to study Imjudo in clinical trials to get a better idea of how it can improve survival times.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"3\"><h3 class=\"faq-heading\">What is the difference between PD-1 and CTLA-4?<\/h3><div><p>PD-1 and CTLA-4 are two different proteins found on T cells. They act in a very similar way as they help T cells know which cells are healthy and which ones are cancerous.<\/p>\n<p>The PD-1 and CTLA-4 responses can be turned off by different proteins that mesothelioma cells create. Fortunately, doctors can use both <a href=\"\/treatment\/immunotherapy\/pd1-and-pdl1-inhibitors\/\">anti-PD-1 drugs<\/a> and CTLA-4 inhibitors so T cells can fight mesothelioma.<\/p>\n<p><a href=\"\/about\/contact\/\">Contact us today<\/a> for help accessing top mesothelioma immunotherapy drugs like PD-1 and CTLA-4 inhibitors.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"4\"><h3 class=\"faq-heading\">What is the most common side effect of CTLA-4 inhibitors?<\/h3><div><p>According to City of Hope, the most common side effect of CTLA-4 inhibitors is a <strong>rash or itchy skin.<\/strong> Other notable side effects include fatigue, nausea and vomiting, and loss of appetite.<\/p>\n<p>Your mesothelioma doctor can help manage any mesothelioma CTLA-4 side effects as they arise.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"5\"><h3 class=\"faq-heading\">What do cytotoxic T lymphocytes do?<\/h3><div><p>Cytotoxic T lymphocytes is the medical term for T cells that <strong>fight cancer and other diseases,<\/strong> according to the National Cancer Institute (NCI).<\/p>\n<p>Cytotoxic T cells use proteins like CTLA-4 to tell cancer cells apart from healthy cells. However, mesothelioma cells make the B7 protein that binds to CTLA-4, preventing cytotoxic T lymphocyte activation (meaning the T cells won\u2019t kill the cancer).<\/p>\n<p>CTLA-4 inhibitors can block CTLA-4 from binding so the T cells can find and destroy mesothelioma tumor cells.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"6\"><h3 class=\"faq-heading\">What cancers can CTLA-4 inhibitors treat?<\/h3><div><p>CTLA-4 inhibitors like Yervoy and Imjudo can help treat <strong>mesothelioma<\/strong>, a rare cancer that develops in the linings of major organs decades after asbestos exposure.<\/p>\n<p>These medications can also treat<strong> non-small cell lung cancer, carcinoma, and advanced melanoma.<\/strong><\/p>\n<\/div><\/div><script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\",\"@type\": \"FAQPage\",\"mainEntity\": [{\"@type\": \"Question\",\"name\": \"What is the function of CTLA-4 in mesothelioma cancer patients?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;Mesothelioma cells use proteins that they create to bind to a protein called CTLA-4 on T cells. This binding tells the T cells not to kill the cancer, allowing it to spread.&lt;\/p&gt;\n&lt;p&gt;Mesothelioma CTLA-4 inhibitors prevent mesothelioma cells from binding so the T cells can destroy them.&lt;\/p&gt;\n\"}},{\"@type\": \"Question\",\"name\": \"What is the new immunotherapy for mesothelioma?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;&lt;strong&gt;Tremelimumab (Imjudo\u00ae) is a new immunotherapy for mesothelioma.&lt;\/strong&gt; Imjudo blocks the CTLA-4 protein on T cells so they can more easily kill cancer, creating what is known as an antitumor response.&lt;\/p&gt;\n&lt;p&gt;Recent studies like the NIBIT-MESO-1 trial show that Imjudo can help both pleural and peritoneal mesothelioma patients live longer. 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Fortunately, doctors can use both anti-PD-1 drugs and CTLA-4 inhibitors so T cells can fight mesothelioma.&lt;\/p&gt;\n&lt;p&gt;Contact us today for help accessing top mesothelioma immunotherapy drugs like PD-1 and CTLA-4 inhibitors.&lt;\/p&gt;\n\"}},{\"@type\": \"Question\",\"name\": \"What is the most common side effect of CTLA-4 inhibitors?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;According to City of Hope, the most common side effect of CTLA-4 inhibitors is a &lt;strong&gt;rash or itchy skin.&lt;\/strong&gt; Other notable side effects include fatigue, nausea and vomiting, and loss of appetite.&lt;\/p&gt;\n&lt;p&gt;Your mesothelioma doctor can help manage any mesothelioma CTLA-4 side effects as they arise.&lt;\/p&gt;\n\"}},{\"@type\": \"Question\",\"name\": \"What do cytotoxic T lymphocytes do?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;Cytotoxic T lymphocytes is the medical term for T cells that &lt;strong&gt;fight cancer and other diseases,&lt;\/strong&gt; according to the National Cancer Institute (NCI).&lt;\/p&gt;\n&lt;p&gt;Cytotoxic T cells use proteins like CTLA-4 to tell cancer cells apart from healthy cells. However, mesothelioma cells make the B7 protein that binds to CTLA-4, preventing cytotoxic T lymphocyte activation (meaning the T cells won\u2019t kill the cancer).&lt;\/p&gt;\n&lt;p&gt;CTLA-4 inhibitors can block CTLA-4 from binding so the T cells can find and destroy mesothelioma tumor cells.&lt;\/p&gt;\n\"}},{\"@type\": \"Question\",\"name\": \"What cancers can CTLA-4 inhibitors treat?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;CTLA-4 inhibitors like Yervoy and Imjudo can help treat &lt;strong&gt;mesothelioma&lt;\/strong&gt;, a rare cancer that develops in the linings of major organs decades after asbestos exposure.&lt;\/p&gt;\n&lt;p&gt;These medications can also treat&lt;strong&gt; non-small cell lung cancer, carcinoma, and advanced melanoma.&lt;\/strong&gt;&lt;\/p&gt;\n\"}}]}<\/script><style type=\"text\/css\">.faq-wrap{background:#E4F4F6;padding:20px 15px;margin:40px -15px}.faq-wrap:first-child{margin-top:0}.faq-wrap:last-child{margin-bottom:0}.faq-wrap .faq{background:#fff;padding:15px;border-radius:10px;box-shadow:0px 20px 20px rgba(0,0,0,0.03);margin:15px 0 0 0}.faq-wrap .faq:first-child{margin-top:0}.faq-wrap .faq .faq-heading{color:#100134;font-size:21px;margin-bottom:15px}.faq-wrap .faq p{margin-bottom:20px;line-height:1.5}.faq-wrap .faq p:last-child{margin-bottom:0}.faq-wrap .faq .learn-more{color:#248AFF;display:block;padding-right:17px;text-align:right;position:relative;line-height:1}.faq-wrap .faq .learn-more:visited{color:#248AFF}.faq-wrap .faq .learn-more:visited:hover,.faq-wrap .faq .learn-more:hover{color:#34d}.faq-wrap .faq .learn-more:after{font-family:\"mesohope\" !important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;content:\"\\e905\";position:absolute;right:0;top:3px}h2.faq-wrap-heading{margin-bottom:25px}@media screen and (min-width: 768px){.faq-wrap{padding:25px 15px}}@media screen and (min-width: 1024px){.faq-wrap{border-radius:10px;margin-left:auto;margin-right:auto;padding:25px}.faq-wrap .faq{padding:25px}.faq-heading{font-size:24px}}<\/style><\/div>\n","protected":false},"excerpt":{"rendered":"<p>What Is CTLA-4 Immunotherapy for Mesothelioma? CTLA-4 inhibitors for mesothelioma, also called anti-CTLA-4 drugs or CTLA-4 antibodies, are a type of immunotherapy that may help you live longer. These inhibitors target a protein called cytotoxic T lymphocyte antigen-4 (CTLA-4) found on regulatory T cells, which your immune system makes to fight cancer. T cells use&hellip;<\/p>\n","protected":false},"author":49,"featured_media":0,"parent":768,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-24292","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/24292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/comments?post=24292"}],"version-history":[{"count":0,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/24292\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/768"}],"wp:attachment":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media?parent=24292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}