{"id":26006,"date":"2024-10-28T18:17:23","date_gmt":"2024-10-28T22:17:23","guid":{"rendered":"https:\/\/www.mesotheliomahope.com\/?page_id=26006"},"modified":"2025-12-23T17:52:46","modified_gmt":"2025-12-23T22:52:46","slug":"car-t-cell-therapy","status":"publish","type":"page","link":"https:\/\/www.mesotheliomahope.com\/treatment\/immunotherapy\/car-t-cell-therapy\/","title":{"rendered":"CAR T-Cell Therapy for Mesothelioma"},"content":{"rendered":"<h2>What Is CAR T-Cell Therapy for Mesothelioma?<\/h2>\n<p>Chimeric antigen receptor (CAR) T-cell therapy is an innovative treatment designed to help the body\u2019s immune system fight <a href=\"\/mesothelioma\/\">mesothelioma<\/a>.<\/p>\n<p>This type of <a href=\"\/treatment\/immunotherapy\/\">immunotherapy<\/a> involves adding special receptors to T cells \u2014 which are naturally produced by your body to fight cancer \u2014 so they can more easily find and destroy mesothelioma cells.<\/p>\n<p>Numerous ongoing clinical trials are exploring how CAR T-cell therapy for mesothelioma could improve patient survival.<\/p>\n<div class=\"quick-facts-shortcode\"><style type=\"text\/css\">.quick-facts-shortcode{border-radius:0 10px 10px 0;border:1px solid #E6E7EC;margin:40px 0;overflow:hidden;padding:20px 20px 20px 24px;position:relative;font-size:17px;box-shadow:0 20px 20px rgba(34,34,34,0.03)}.quick-facts-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #fff 100%)}.quick-facts-shortcode .quick-facts-shortcode-heading{color:#100134;display:block;font-size:22px;margin-bottom:20px}.quick-facts-shortcode .content ul{margin-left:24px;margin-bottom:0}.quick-facts-shortcode .content ul li:before{width:6px;height:6px;top:10px;left:-22px;-webkit-border-radius:50%;-moz-border-radius:50%;border-radius:50%;border:none;background:#F38A6B}.quick-facts-shortcode .content ul li:last-child{margin-bottom:0}.quick-facts-shortcode .content p:empty{display:none}@media screen and (min-width: 1024px){.quick-facts-shortcode{padding:25px 25px 25px 30px}.quick-facts-shortcode-heading{font-size:22px;margin-bottom:20px}}<\/style><h3 class=\"quick-facts-shortcode-heading\">Key Facts on CAR T-Cell Therapy for Mesothelioma<\/h3><div class=\"content\"><ul>\n<li>CAR T-cell therapy is currently being studied to treat <a href=\"\/mesothelioma\/pleural\/\">pleural mesothelioma<\/a> and <a href=\"\/mesothelioma\/peritoneal\/\">peritoneal mesothelioma<\/a>, the two most common types of this cancer.<\/li>\n<li>Chimeric antigen receptor t-cell therapy may be combined with additional treatments like chemotherapy or other immunotherapies for best results.<\/li>\n<li>Mesothelioma patients lived for<strong> nearly 2 years on average<\/strong> when treated with CAR-T cell therapy and Keytruda\u00ae (pembrolizumab) in a 2021 study.<\/li>\n<\/ul>\n<\/div><\/div>\n<p>The U.S. Food and Drug Administration (FDA) has already approved various types of CAR T-cell therapies to treat other cancers. Hopefully, CAR T-cell therapy for mesothelioma will become another treatment option for this rare cancer.<\/p>\n<p>Download our <strong>Free Immunotherapy Guide<\/strong> to learn more about CAR T-cell therapy for mesothelioma and how we can help you pursue this treatment.<\/p>\n<div id=\"23756\" class=\"one-off-23756 widget widget_oscar-vque one-off\" data-vqueid=\"23756\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-23756{margin:60px auto}.one-off-23756 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:linear-gradient(90deg,#B1E5EA 0,#0FAEBF 100%);padding:20px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:350px;margin:0 auto}.one-off-23756 a::before{background:#EDF8F9;border-radius:0 0 50% 50%;content:'';position:absolute;top:0;height:87%;width:140%;left:-70px;z-index:0}.one-off-23756 .vque-content,.one-off-23756 .image-wrap{z-index:1;position:relative}.one-off-23756 .image-wrap{max-width:163px;display:block;margin:15px auto -21px}.one-off-23756 .heading{font-size:24px;line-height:28px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-23756 ul{max-width:160px;list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:27px}.one-off-23756 ul li{margin:0;position:relative;padding-left:28px}.one-off-23756 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:14px;height:14px;display:block;position:absolute;left:0;top:7px;border-radius:50%;color:#fff;font-size:7px;text-align:center;line-height:14px}.one-off-23756 p{text-align:center}.one-off-23756 .button{padding:12px 16px}@media screen and (min-width:768px){.one-off-23756 a{max-width:620px;padding:25px 50px 29px;border-radius:0 0 4px 4px}.one-off-23756 a::before{border-radius:0 0 100% 0;height:83%;width:70%;right:-70px;left:unset}.one-off-23756 a::after{background:#EDF8F9;border-radius:0;content:'';position:absolute;top:0;height:82%;width:50%;left:0;z-index:0}.one-off-23756 .heading{text-align:left;margin:5px 0 25px}.one-off-23756 ul{margin:-10px 0 22px}.one-off-23756 .image-wrap{max-width:unset;position:absolute;right:0;bottom:0;margin:0 0 -2px}.one-off-23756 p{text-align:left}}<\/style><a href=\"\/immunotherapy-guide\/\" title=\"Get Your Free Immunotherapy Guide\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Your Free Immunotherapy Guide Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Your Free Immunotherapy Guide<\/strong>\r\n        <ul>\r\n            <li>When it\u2019s used<\/li>\r\n            <li>Types of drugs<\/li>\r\n            <li>Side effects<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Your Free Guide\">Get Your Free Guide<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/03\/download-immunotherapy-guide.png\" alt=\"Free Immunotherapy Guide\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>How Does CAR T-Cell Therapy Work to Treat Mesotelioma?<\/h2>\n<p>CAR T-cell therapy for mesothelioma helps modify your body\u2019s T cells to kill cancer.<\/p>\n<p>The immune system produces T cells to help destroy threats like cancer. To do this, the T cells use receptors that attach to <strong>antigens<\/strong>, proteins found on the surface of mesothelioma cells.<\/p>\n<p>However, the antigens on mesothelioma cells may not match up with the receptors that your T cells have. As a result, the T cells won\u2019t be able to recognize and destroy cancer.<\/p>\n<p>Through CAR T-cell therapy, doctors can add the right receptors so that T cells can fight mesothelioma.<\/p>\n<h3>Mesothelioma CAR T-Cell Therapy Process<\/h3>\n<p>Doctors administer CAR T-cell therapy for mesothelioma using a couple of different steps.<\/p>\n<p><strong>Steps in the process include:<\/strong><\/p>\n<ol>\n<li><strong>Getting a basic health examination:<\/strong> Before starting CAR T-cell therapy, doctors will assess your overall health, including organ function, to ensure you\u2019re a good candidate for the treatment.<\/li>\n<li><strong>Collecting T cells:<\/strong> Doctors take a sample of blood that contains T cells. They then use a process called apheresis to remove T cells from the blood sample. Apheresis will be performed over a few hours at the hospital\u2019s oncology (cancer) department.<\/li>\n<li><strong>Adding receptors:<\/strong> Once the T cells are extracted, doctors add a gene with the receptor to help them identify and kill mesothelioma cells. Doctors then create a batch of T cells to treat the patient. This process takes about three weeks.<\/li>\n<li><strong>Providing chemotherapy:<\/strong> A mild dose of a <a href=\"\/treatment\/chemotherapy\/\">chemotherapy<\/a> drug like cyclophosphamide may be given before adding the CAR T cells into the body. These medications may help improve the CAR T cells\u2019 ability to kill cancer.<\/li>\n<li><strong>Administering CAR T cells:<\/strong> Once the CAR T cells are ready, doctors put them back into the patient\u2019s body through an IV, which takes about 10 minutes.<\/li>\n<\/ol>\n<p>After the CAR T-cell infusion, patients are closely monitored for about 30 days to watch for side effects and ensure the treatment is working. This can include inpatient care or follow-up visits, depending on your response to the treatment.<\/p>\n<p><a href=\"\/about\/contact\/\">Contact our team now<\/a> for help accessing CAR T-cell therapy for mesothelioma and other top treatments.<\/p>\n<h2>Types of CAR T-Cell Therapies for Mesothelioma<\/h2>\n<p>Clinical trials are studying several CAR T-cell therapies that could help mesothelioma patients live longer.<\/p>\n<p><strong>Notable types of mesothelioma CAR T-cell therapies include:<\/strong><\/p>\n<ul>\n<li><strong>A2B694:<\/strong> This helps T cells target cancer cells with an antigen called mesothelin. In mesothelioma and other cancers that form solid tumors, mesothelin is \u201coverexpressed,\u201d meaning the cells have too many copies of it.<\/li>\n<li><strong>SynKIR-110:<\/strong> This modifies T cells so they can find mesothelioma cells that are expressing mesothelin. The FDA fast-tracked SynKIR-110 in 2023 due to its potential in helping patients.<\/li>\n<li><strong>SKM9-2:<\/strong> This allows T cells to identify and destroy mesothelioma cells with a protein called HEG homolog 1.<\/li>\n<\/ul>\n<p>Other CAR T-cell therapies like Kymriah\u00ae (tisagenlecleucel) have also been approved by the FDA in treating blood cancers like leukemia and lymphoma.<\/p>\n<div class=\"blockquote-w-image \"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2024\/10\/Dr_Daniel_H_Sterman.jpeg\" alt=\"\" \/><blockquote><p>&#8220;The first approvals of CAR T-cell therapies for treatment of malignancy (cancer) have really led to, in many cases, long-term remissions and even cures of what had previously been incurable malignancies.&#8221;<\/p>\n<footer>&ndash;<cite> Dr. Daniel Sterman, mesothelioma specialist at NYU Langone Health<\/cite><\/footer><\/blockquote><style type=\"text\/css\">.blockquote-w-image{position:relative;margin:40px auto}.blockquote-w-image blockquote{background:none;border-left:none;padding:25px;margin-top:0;padding-bottom:0;font-size:inherit;line-height:inherit}.blockquote-w-image blockquote footer cite{font-size:inherit}.blockquote-w-image blockquote p{margin-bottom:0}.blockquote-w-image img{width:100px;border:none;border-radius:100%;box-shadow:none;position:relative;margin:0 auto}.blockquote-w-image.alternative{margin:60px auto}.blockquote-w-image.alternative blockquote{padding:25px 25px 25px 80px;padding-bottom:25px;background-color:#E4F4F6}.blockquote-w-image.alternative img{position:absolute;left:20px;top:25px;z-index:1;width:50px;border:1px solid #fff;box-shadow:0 0 10px rgba(34,34,34,0.2);border-radius:100%}.blockquote-w-image.with-border{background:none;border-left:4px solid #0FAEBF}.blockquote-w-image.with-border blockquote{background:none;border-radius:0;padding:10px 25px}.blockquote-w-image.with-border blockquote footer cite{font-size:inherit}.blockquote-w-image blockquote:before{display:none}@media screen and (min-width: 769px){.blockquote-w-image img{position:absolute;left:0;top:0}.blockquote-w-image blockquote{padding:0 25px 0 125px;min-height:90px}}@media screen and (min-width: 1024px){.blockquote-w-image.alternative blockquote{padding-left:105px}.blockquote-w-image.alternative blockquote footer cite{font-size:16px}.entry-content .blockquote-w-image.alternative img{width:60px;left:25px}}<\/style><\/div>\n<p>As research on this emerging treatment continues, there\u2019s hope that CAR T-cell therapy approval for mesothelioma is on the horizon, bringing new options to patients.<\/p>\n<h2>Who Is Eligible for Mesothelioma CAR-T Cell Therapy?<\/h2>\n<p>Several factors determine whether you\u2019re eligible for CAR T-cell therapy.<\/p>\n<p><strong>These include your:<\/strong><\/p>\n<ul>\n<li><strong>Mesothelioma stage:<\/strong> CAR T-cell therapies may be available for at any stage of mesothelioma, though doctors will want to make sure late-stage patients can safely tolerate the treatment ahead of time.<\/li>\n<li><strong>Mesothelioma cell type:<\/strong> <a href=\"\/mesothelioma\/cell-types\/epithelioid\/\">Epithelioid mesothelioma<\/a> expresses the antigen mesothelin at very high levels, while sarcomatoid mesothelioma does not. You may not qualify for CAR T-cell therapy targeting mesothelin if you\u2019ve been diagnosed with the sarcomatoid cell type.<\/li>\n<li><strong>Overall health:<\/strong> CAR T-cell therapy can potentially cause serious side effects, so you should be in good overall health in order to receive the treatment.<\/li>\n<\/ul>\n<p>A mesothelioma oncologist (cancer doctor) can help determine if CAR T-cell therapy could be right for you.<\/p>\n<p>Use our <strong>Free Doctor Match<\/strong> to get help connecting with mesothelioma specialists in your area.<\/p>\n<div id=\"25223\" class=\"one-off-25223 widget widget_oscar-vque one-off\" data-vqueid=\"25223\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-25223{margin:60px auto}.one-off-25223 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:#e4f4f6;padding:20px 25px 200px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:360px;margin:0 auto}.one-off-25223 a::before{background:#0FAEBF;border-radius:50% 50% 0 0;content:'';position:absolute;bottom:0;height:19%;width:135%;left:-60px;z-index:0}.one-off-25223 .vque-content,.one-off-25223 .image-wrap{z-index:1;position:relative}.one-off-25223 .image-wrap{width:100%;position:absolute;left:-10px;bottom:-15px}.one-off-25223 .image-wrap img{position:absolute;bottom:0;width:100%;max-width:unset;left:0}.one-off-25223 .heading{font-size:27px;line-height:33px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-25223 ul{list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:26px}.one-off-25223 ul li{margin:0 0 15px;position:relative;padding-left:35px}.one-off-25223 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:21px;height:21px;display:block;position:absolute;left:0;top:4px;border-radius:50%;color:#fff;font-size:11px;text-align:center;line-height:21px}.one-off-25223 p{text-align:center}.one-off-25223 .button{padding:12px 16px;display:block}@media screen and (min-width:768px){.one-off-25223 a{max-width:620px;padding:30px 30px 35px;border-radius:0 0 4px 4px}.one-off-25223 a::before{border-radius:50%;height:155%;width:150%;right:-550px;left:unset;bottom:-295px}.one-off-25223 .heading{text-align:left;margin:2px 0 25px;max-width:unset;font-size:24px}.one-off-25223 ul{margin:-7px 0 30px;max-width:365px;line-height:23px}.one-off-25223 ul li::before{top:1px}.one-off-25223 .image-wrap{max-width:unset;position:absolute;right:-25px;bottom:-35px;margin:0 0 -2px;left:unset;width:380px}.one-off-25223 .image-wrap img{position:relative;bottom:0;left:0;width:380px}.one-off-25223 .button{display:inline-block;padding:14px 25px}.one-off-25223 p{text-align:left}}@media screen and (min-width:1150px){.one-off-25223 a{padding:30px}}<\/style><a href=\"\/get-matched\/\" title=\"Get Matched With a Mesothelioma Doctor\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Matched With a Mesothelioma Doctor Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Matched With a Mesothelioma Doctor<\/strong>\r\n        <ul>\r\n            <li>Find top specialists near you<\/li>\r\n            <li>Seek compensation for travel & care<\/li>\r\n            <li>Get medical guidance<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Matched Now\">Get Matched Now<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/07\/Doctors-ad.png\" alt=\"Get Matched With a Mesothelioma Doctor\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>The Role of CAR T-Cell Therapy in Mesothelioma Treatment<\/h2>\n<p>CAR T-cell therapy can be an important part of <a href=\"\/treatment\/\">mesothelioma treatment<\/a>, especially when combined with other therapies like surgery, chemotherapy, and radiation.<\/p>\n<p><strong>CAR T-cell therapy for mesothelioma can be used with:<\/strong><\/p>\n<ul>\n<li><strong>Chemotherapy:<\/strong> Doctors may use chemotherapy before administering CAR T-cell therapy to make the latter treatment more effective.<\/li>\n<li><strong>Other immunotherapies:<\/strong> A 2021 study published in <em>Cancer Discovery<\/em> noted that combining CAR T cell therapy with another immunotherapy, <a href=\"\/treatment\/immunotherapy\/keytruda\/\">Keytruda<\/a>, helped malignant pleural mesothelioma patients live longer.<\/li>\n<li><strong><a href=\"\/treatment\/radiation\/\">Radiation therapy<\/a>:<\/strong> Patients can receive radiotherapy (which uses high-powered beams of energy to damage cancer cells) prior to CAR T-cell therapy.<\/li>\n<li><strong><a href=\"\/treatment\/surgery\/\">Surgery<\/a>:<\/strong> CAR T-cell therapy can be administered before surgery to shrink tumors or after surgery to target any remaining cancer cells.<\/li>\n<li><strong><a href=\"\/treatment\/targeted-therapies\/\">Targeted therapies<\/a>:<\/strong> These medications kill cancer cells without harming healthy tissue and may be used before CAR T-cell therapy.<\/li>\n<\/ul>\n<p>Doctors may also be able to provide CAR T-cell therapy when other treatments don\u2019t work or if the patient experiences a recurrence (where the cancer comes back despite earlier therapies).<\/p>\n<h2>CAR T-Cell Therapy Success Rate and Mesothelioma Prognosis<\/h2>\n<p>Recent and ongoing trials reveal that CAR T-cell therapy has shown promise in treating mesothelioma, helping improve <a href=\"\/mesothelioma\/prognosis\/\">prognosis (overall health outlook)<\/a> in patients.<\/p>\n<h3>CAR T-Cell Therapy Survival Rates &amp; Life Expectancy<\/h3>\n<p>Mesothelioma prognosis is measured using survival rates (percentage of patients living a set time period following treatment) and life expectancy (average life span after treatment).<\/p>\n<p>A 2021 study in <em>Cancer Discovery<\/em> found that pleural mesothelioma patients treated with CAR T-cell therapy and Keytruda had a 1-year survival rate of 83%. This is almost double the average 1-year <a href=\"\/mesothelioma\/prognosis\/survival-rate\/\">survival rate for mesothelioma<\/a>, which is 43.7%.<\/p>\n<p>Additionally, this study noted that the overall <a href=\"\/mesothelioma\/prognosis\/life-expectancy\/\">mesothelioma life expectancy<\/a> of these patients was <strong>23.9 months<\/strong>. In comparison, the average life expectancy of pleural mesothelioma is 18 months.<\/p>\n<p>Some patients in the study also achieved <a href=\"\/mesothelioma\/prognosis\/remission-recurrence\/\">mesothelioma remission<\/a>, where signs and symptoms of the cancer disappear. For example, one patient was <strong>in complete remission for<\/strong> <strong>over 2 years<\/strong> after receiving CAR T-cell therapy and Keytruda.<\/p>\n<div class=\"callout-shortcode\"><style type=\"text\/css\">.callout-shortcode{background:#EDF8F9;border-radius:0 10px 10px 0;padding:20px 20px 20px 24px;margin:40px 0;max-width:860px;position:relative}.callout-shortcode:before{content:\" \";position:absolute;top:0;bottom:0;width:4px;height:100%;left:0;background:linear-gradient(180deg, #0FAEBF 0%, #EDF8F9 100%)}.callout-shortcode .callout-shortcode-heading{color:#100134;font-size:22px;display:block;margin:0 0 15px}.callout-shortcode:first-child{margin-top:0}.callout-shortcode:last-child{margin-bottom:0}.callout-shortcode .img-wrap{margin-bottom:20px}.callout-shortcode.hope>strong{padding-top:17px;padding-bottom:15px;padding-left:74px}.callout-shortcode.hope .img-wrap{left:22px;position:absolute;top:20px;width:59px}.callout-shortcode.hope .img-wrap:before{background:#fff url(\/wp-content\/uploads\/2024\/02\/mh-icon-65.png);background-position:center;background-repeat:no-repeat;background-size:70%;border-radius:30px;bottom:-10px;content:\"\";display:block;height:30px;position:absolute;right:-10px;width:30px}@media screen and (min-width: 768px){.callout-shortcode{padding:25px 25px 25px 34px}.callout-shortcode .callout-shortcode-heading{font-size:24px}.callout-shortcode .img-wrap{margin-bottom:0}.callout-shortcode.has-img{min-height:170px;padding-left:175px}.callout-shortcode.has-img .img-wrap{position:absolute;left:29px;top:25px;width:119px}.callout-shortcode.hope.has-img{padding-left:170px}.callout-shortcode.hope>strong{padding:0}.callout-shortcode.hope .img-wrap{width:109px}.callout-shortcode.hope .img-wrap:before{background-size:66%;bottom:-15px;height:42px;width:42px}}<\/style><div class=\"content\"><p>Call <strong><a href=\"tel:+18666088933\" title=\"Click to call (866) 608-8933\" class=\"in-content-tel-link\" data-ce-category=\"Click to Call\" data-ce-label=\"(866) 608-8933\">(866) 608-8933<\/a><\/strong> for help finding trials testing CAR T-cell therapies for mesothelioma and other treatments that could improve your life expectancy.<\/p>\n<\/div><\/div>\n<h2>Mesothelioma CAR T-Cell Therapy Side Effects<\/h2>\n<p>While CAR T-cell therapy can be a powerful treatment for mesothelioma, it may also cause side effects.<\/p>\n<p>One of the most notable side effects is cytokine release syndrome (CRS). This occurs when the immune system overreacts to an immunotherapy drug, and it can cause nausea, fatigue, and a fever.<\/p>\n<p><strong>Other side effects of CAR T-cell therapy for mesothelioma can include:<\/strong><\/p>\n<\/p>\n<ul class='columns-2'>\n<li>Allergic reactions<\/li>\n<li>Chills<\/li>\n<li>Confusion or agitation<\/li>\n<li>Difficulty breathing<\/li>\n<li>Dizziness<\/li>\n<li>Headaches<\/li>\n<li>Muscle or joint pain<\/li>\n<li>Nausea, vomiting, and diarrhea<\/li>\n<li>Seizures<\/li>\n<li>Shaking or tremors<\/li>\n<li>Trouble speaking<\/li>\n<\/ul>\n<p>\n<p>Always make sure to see a specialist promptly if you are experiencing severe side effects after undergoing CAR T-cell therapy for mesothelioma.<\/p>\n<h2>Clinical Trials on CAR T-Cell Therapy for Mesothelioma<\/h2>\n<p><a href=\"\/treatment\/clinical-trials\/\">Clinical trials<\/a> are studying how CAR T-cell therapy can help mesothelioma patients live longer.<\/p>\n<p><strong>Ongoing CAR T-cell cancer research studies include:<\/strong><\/p>\n<ul>\n<li><strong>BASECAMP-1 study:<\/strong> Researchers are studying how cancer cells lose the human leukocyte antigen (which helps them hide from the immune system) and how to store a patient\u2019s T cells for use in future treatment. This study is expected to be finished in 2026. Patients can join if they have mesothelioma that\u2019s unresectable (not surgically treatable).<\/li>\n<li><strong>EVEREST-2 study:<\/strong> This is testing a CAR T-cell therapy called A2B694, which targets mesothelin in mesothelioma, <a href=\"\/cancer\/lung-cancer\/\">lung cancer<\/a>, ovarian cancer, and other cancers. It is currently recruiting patients and is expected to have results in 2029.<\/li>\n<li><strong>Mesothelin-targeted CAR T-cell study:<\/strong> Doctors are infusing CAR T cells with <a href=\"\/treatment\/immunotherapy\/checkpoint-inhibitors\/\">immune checkpoint inhibitors<\/a> (another type of immunotherapy). They are hoping this combination will make CAR T-cell therapy more potent.<\/li>\n<li><strong>STAR-101 study:<\/strong> Doctors are studying SynKIR-110 for use in treating mesothelioma, <a href=\"\/cancer\/ovarian-cancer\/\">ovarian cancer<\/a>, primary peritoneal cancer, and more in this phase 1 trial. Like A2B694, SynKIR-110 will target mesothelin-expressing cancer cells.<\/li>\n<\/ul>\n<p>More clinical trials testing CAR T-cell therapy for mesothelioma are likely on the horizon as doctors continue to study this new treatment.<\/p>\n<div class=\"blockquote-w-image \"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2022\/12\/dr-richard-alexander.png\" alt=\"\" \/><blockquote><p>&#8220;There are researchers who are now testing whether or not CAR T cells administered directly into a mesothelioma tumor could have some more dramatic effect than trying to give them intravenously. I think that kind of research holds great promise, but it&#8217;s very preliminary.&#8221;<\/p>\n<footer>&ndash;<cite> Dr. Richard Alexander, mesothelioma specialist at the Rutgers Cancer Institute of New Jersey<\/cite><\/footer><\/blockquote><style type=\"text\/css\">.blockquote-w-image{position:relative;margin:40px auto}.blockquote-w-image blockquote{background:none;border-left:none;padding:25px;margin-top:0;padding-bottom:0;font-size:inherit;line-height:inherit}.blockquote-w-image blockquote footer cite{font-size:inherit}.blockquote-w-image blockquote p{margin-bottom:0}.blockquote-w-image img{width:100px;border:none;border-radius:100%;box-shadow:none;position:relative;margin:0 auto}.blockquote-w-image.alternative{margin:60px auto}.blockquote-w-image.alternative blockquote{padding:25px 25px 25px 80px;padding-bottom:25px;background-color:#E4F4F6}.blockquote-w-image.alternative img{position:absolute;left:20px;top:25px;z-index:1;width:50px;border:1px solid #fff;box-shadow:0 0 10px rgba(34,34,34,0.2);border-radius:100%}.blockquote-w-image.with-border{background:none;border-left:4px solid #0FAEBF}.blockquote-w-image.with-border blockquote{background:none;border-radius:0;padding:10px 25px}.blockquote-w-image.with-border blockquote footer cite{font-size:inherit}.blockquote-w-image blockquote:before{display:none}@media screen and (min-width: 769px){.blockquote-w-image img{position:absolute;left:0;top:0}.blockquote-w-image blockquote{padding:0 25px 0 125px;min-height:90px}}@media screen and (min-width: 1024px){.blockquote-w-image.alternative blockquote{padding-left:105px}.blockquote-w-image.alternative blockquote footer cite{font-size:16px}.entry-content .blockquote-w-image.alternative img{width:60px;left:25px}}<\/style><\/div>\n<p>If you meet the specific criteria outlined in a CAR T-cell therapy trial, you may be able to receive this treatment.<\/p>\n<h2>How Much Does Mesothelioma CAR T-Cell Therapy Cost?<\/h2>\n<p>CAR T-cell therapy for mesothelioma is currently only available in clinical trials, which cost nothing to join.<\/p>\n<p>That said, you could face many other significant expenses related to your mesothelioma diagnosis. Medical costs for testing and treatment can easily exceed<strong> $400,000.<\/strong> You could also face travel bills, loss of income, and other unexpected financial burdens.<\/p>\n<p><span style=\"font-weight: 400;\">However, you may qualify for financial compensation to help pay for your mesothelioma treatment. <\/span>Download our <strong>Free Immunotherapy Guide<\/strong> now to learn more.<\/p>\n<div id=\"23756\" class=\"one-off-23756 widget widget_oscar-vque one-off\" data-vqueid=\"23756\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-23756{margin:60px auto}.one-off-23756 a{box-shadow:0 4px 4px 0 rgba(0,0,0,.25);display:block;background:linear-gradient(90deg,#B1E5EA 0,#0FAEBF 100%);padding:20px;text-decoration:none;color:inherit;position:relative;overflow:hidden;max-width:350px;margin:0 auto}.one-off-23756 a::before{background:#EDF8F9;border-radius:0 0 50% 50%;content:'';position:absolute;top:0;height:87%;width:140%;left:-70px;z-index:0}.one-off-23756 .vque-content,.one-off-23756 .image-wrap{z-index:1;position:relative}.one-off-23756 .image-wrap{max-width:163px;display:block;margin:15px auto -21px}.one-off-23756 .heading{font-size:24px;line-height:28px;text-align:center;display:block;max-width:340px;margin:5px auto 25px}.one-off-23756 ul{max-width:160px;list-style:none;margin:-10px auto 22px;text-align:left;font-size:16px;line-height:27px}.one-off-23756 ul li{margin:0;position:relative;padding-left:28px}.one-off-23756 ul li::before{font-family:\"mesohope\"!important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;content:\"\\e904\";background:#0FAEBF;width:14px;height:14px;display:block;position:absolute;left:0;top:7px;border-radius:50%;color:#fff;font-size:7px;text-align:center;line-height:14px}.one-off-23756 p{text-align:center}.one-off-23756 .button{padding:12px 16px}@media screen and (min-width:768px){.one-off-23756 a{max-width:620px;padding:25px 50px 29px;border-radius:0 0 4px 4px}.one-off-23756 a::before{border-radius:0 0 100% 0;height:83%;width:70%;right:-70px;left:unset}.one-off-23756 a::after{background:#EDF8F9;border-radius:0;content:'';position:absolute;top:0;height:82%;width:50%;left:0;z-index:0}.one-off-23756 .heading{text-align:left;margin:5px 0 25px}.one-off-23756 ul{margin:-10px 0 22px}.one-off-23756 .image-wrap{max-width:unset;position:absolute;right:0;bottom:0;margin:0 0 -2px}.one-off-23756 p{text-align:left}}<\/style><a href=\"\/immunotherapy-guide\/\" title=\"Get Your Free Immunotherapy Guide\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Get Your Free Immunotherapy Guide Ad\"><div>\r\n    <div class=\"vque-content\">\r\n        <strong class=\"heading\">Get Your Free Immunotherapy Guide<\/strong>\r\n        <ul>\r\n            <li>When it\u2019s used<\/li>\r\n            <li>Types of drugs<\/li>\r\n            <li>Side effects<\/li>\r\n        <\/ul>\r\n        <p><strong class=\"button arrow\" title=\"Get Your Free Guide\">Get Your Free Guide<\/strong><\/p>\r\n    <\/div>\r\n    <div class=\"image-wrap\"><img decoding=\"async\"  src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"\/wp-content\/uploads\/2024\/03\/download-immunotherapy-guide.png\" alt=\"Free Immunotherapy Guide\" class=\"lazyload\" ><\/div>\r\n<\/div><\/a><\/div>\n<h2>What Happens if Mesothelioma CAR T-Cell Therapy Fails?<\/h2>\n<p>If mesothelioma CAR T-cell therapy fails or you experience significant side effects due to treatment toxicity, your doctor can determine next steps to help you.<\/p>\n<p>While mesothelioma is very aggressive, <strong>you may still have options<\/strong> even if CAR T-cell therapy is not right for you.<\/p>\n<p>Standard treatments, <a href=\"\/treatment\/palliative\/\">palliative (pain-relieving) care<\/a>, and other new therapies being tested in clinical trials are all options that can help you manage mesothelioma if CAR T-cell therapy isn\u2019t a good fit.<\/p>\n<h2>Learn if CAR T-Cell Therapy Is Right for You<\/h2>\n<p>CAR T-cell therapy is a groundbreaking option for treating mesothelioma and other types of cancers.<\/p>\n<p>If you or a loved one has been diagnosed with mesothelioma, a cancer specialist can determine if CAR T-cell therapy is a good fit with your current treatment plan.<\/p>\n<p>You can also reach out to Mesothelioma Hope for personalized guidance and support.<\/p>\n<p><strong>Our Patient Advocates are standing by to help you:<\/strong><\/p>\n<ul>\n<li>Connect with experienced mesothelioma doctors<\/li>\n<li>Find and enroll in clinical trials at no cost to you<\/li>\n<li>Pursue compensation for treatment and other expenses<\/li>\n<\/ul>\n<p>Call <strong><a href=\"tel:+18666088933\" title=\"Click to call (866) 608-8933\" class=\"in-content-tel-link\" data-ce-category=\"Click to Call\" data-ce-label=\"(866) 608-8933\">(866) 608-8933<\/a><\/strong> or download our <a href=\"\/immunotherapy-guide\/\">Free Immunotherapy Guide<\/a> now to get started.<\/p>\n<div class=\"faq-wrap\"><h2 class=\"faq-wrap-heading\">CAR T-Cell Therapy for Mesothelioma FAQs<\/h2><div class=\"faq\" data-faq=\"1\"><h3 class=\"faq-heading\">What are CAR T cells for mesothelioma?<\/h3><div><p>CAR T cells for mesothelioma are <strong>specially modified T cells<\/strong> that can more easily kill cancer cells.<\/p>\n<p>These cells have been given chimeric antigen receptors (CARS) in a lab that can bind to antigens, specific proteins found on cancer cell surfaces.<\/p>\n<p>The body normally makes T cells as part of its immune response but without the special receptors, it\u2019s harder for them to kill mesothelioma cells.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"2\"><h3 class=\"faq-heading\">What is the best immunotherapy for mesothelioma?<\/h3><div><p>CAR T-cell therapy for mesothelioma is one of the best new immunotherapy treatments currently being studied in clinical trials. This therapeutic option helps the body\u2019s T cells more easily destroy mesothelioma tumor cells.<\/p>\n<p><a href=\"\/about\/contact\/\">Contact our team now<\/a> for help finding the best type of mesothelioma immunotherapy for your diagnosis.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"3\"><h3 class=\"faq-heading\">What is the survival rate of CAR T-cell therapy?<\/h3><div><p>Mesothelioma patients have encouraging survival rates when treated with CAR T-cell therapy.<\/p>\n<p>A 2021 <em>Cancer Discovery<\/em> report noted that the 1-year survival rate was <strong>83% in pleural mesothelioma patients<\/strong> treated with CAR T-cell therapy and the immune checkpoint inhibitor Keytruda\u00ae.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"4\"><h3 class=\"faq-heading\">How long does CAR T-cell therapy take to work?<\/h3><div><p>It only takes <strong>a couple of weeks<\/strong> for mesothelioma CAR T-cell therapy to work. Doctors found that CAR T-cell therapy of solid tumors reduced a pleural mesothelioma patient\u2019s tumors by nearly 30% in just one month.<\/p>\n<p>Each patient is different, though. If you\u2019re concerned that CAR T-cell therapy isn\u2019t working in your case, speak with your mesothelioma doctor.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"5\"><h3 class=\"faq-heading\">Can you die from CAR T-cell therapy?<\/h3><div><p>You are very unlikely to die from mesothelioma CAR T-cell therapy.<\/p>\n<p>Cytokine release syndrome (CRS) is a potentially fatal side effect of CAR T-cell therapy. However, your <a href=\"\/treatment\/doctors\/\">mesothelioma doctor<\/a> will closely monitor any side effects that you develop and work to address them before severe complications develop.<\/p>\n<p>In a 2021 <em>Cancer Discovery<\/em> study, no mesothelioma patients treated with CAR T-cell therapy experienced severe CRS. CAR T-cell therapy <strong>death rates are incredibly low<\/strong>, with most fatalities stemming from cancer recurrence or infections \u2014 not the treatment itself.<\/p>\n<\/div><\/div><script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\",\"@type\": \"FAQPage\",\"mainEntity\": [{\"@type\": \"Question\",\"name\": \"What are CAR T cells for mesothelioma?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;CAR T cells for mesothelioma are &lt;strong&gt;specially modified T cells&lt;\/strong&gt; that can more easily kill cancer cells.&lt;\/p&gt;\n&lt;p&gt;These cells have been given chimeric antigen receptors (CARS) in a lab that can bind to antigens, specific proteins found on cancer cell surfaces.&lt;\/p&gt;\n&lt;p&gt;The body normally makes T cells as part of its immune response but without the special receptors, it\u2019s harder for them to kill mesothelioma cells.&lt;\/p&gt;\n\"}},{\"@type\": \"Question\",\"name\": \"What is the best immunotherapy for mesothelioma?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;CAR T-cell therapy for mesothelioma is one of the best new immunotherapy treatments currently being studied in clinical trials. 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CAR T-cell therapy &lt;strong&gt;death rates are incredibly low&lt;\/strong&gt;, with most fatalities stemming from cancer recurrence or infections \u2014 not the treatment itself.&lt;\/p&gt;\n\"}}]}<\/script><style type=\"text\/css\">.faq-wrap{background:#E4F4F6;padding:20px 15px;margin:40px -15px}.faq-wrap:first-child{margin-top:0}.faq-wrap:last-child{margin-bottom:0}.faq-wrap .faq{background:#fff;padding:15px;border-radius:10px;box-shadow:0px 20px 20px rgba(0,0,0,0.03);margin:15px 0 0 0}.faq-wrap .faq:first-child{margin-top:0}.faq-wrap .faq .faq-heading{color:#100134;font-size:21px;margin-bottom:15px}.faq-wrap .faq p{margin-bottom:20px;line-height:1.5}.faq-wrap .faq p:last-child{margin-bottom:0}.faq-wrap .faq .learn-more{color:#248AFF;display:block;padding-right:17px;text-align:right;position:relative;line-height:1}.faq-wrap .faq .learn-more:visited{color:#248AFF}.faq-wrap .faq .learn-more:visited:hover,.faq-wrap .faq .learn-more:hover{color:#34d}.faq-wrap .faq .learn-more:after{font-family:\"mesohope\" !important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;content:\"\\e905\";position:absolute;right:0;top:3px}h2.faq-wrap-heading{margin-bottom:25px}@media screen and (min-width: 768px){.faq-wrap{padding:25px 15px}}@media screen and (min-width: 1024px){.faq-wrap{border-radius:10px;margin-left:auto;margin-right:auto;padding:25px}.faq-wrap .faq{padding:25px}.faq-heading{font-size:24px}}<\/style><\/div>\n","protected":false},"excerpt":{"rendered":"<p>What Is CAR T-Cell Therapy for Mesothelioma? Chimeric antigen receptor (CAR) T-cell therapy is an innovative treatment designed to help the body\u2019s immune system fight mesothelioma. This type of immunotherapy involves adding special receptors to T cells \u2014 which are naturally produced by your body to fight cancer \u2014 so they can more easily find&hellip;<\/p>\n","protected":false},"author":49,"featured_media":0,"parent":768,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-26006","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/26006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/comments?post=26006"}],"version-history":[{"count":0,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/26006\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/768"}],"wp:attachment":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media?parent=26006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}