{"id":834,"date":"2020-04-17T13:25:05","date_gmt":"2020-04-17T17:25:05","guid":{"rendered":"https:\/\/www.mesotheliomahope.com\/?page_id=834"},"modified":"2025-12-18T17:33:45","modified_gmt":"2025-12-18T22:33:45","slug":"gemcitabine","status":"publish","type":"page","link":"https:\/\/www.mesotheliomahope.com\/treatment\/chemotherapy\/drugs\/gemcitabine\/","title":{"rendered":"Gemcitabine"},"content":{"rendered":"<h2>What Is Gemcitabine?<\/h2>\n<p>For many mesothelioma patients, the most effective chemotherapy combination is the platinum-based chemo drug cisplatin and pemetrexed (Alimta).<\/p>\n<p>In most cases, gemcitabine chemotherapy is only used when a patient can\u2019t tolerate <a href=\"\/treatment\/chemotherapy\/drugs\/cisplatin\/\">cisplatin<\/a>, has an allergy, or there\u2019s some other reason the cisplatin and <a href=\"\/treatment\/chemotherapy\/drugs\/alimta\/\">pemetrexed<\/a> combination shouldn\u2019t be used. Gemcitabine is not as harsh as cisplatin and some other chemotherapy drugs.<\/p>\n<p>Gemcitabine is often combined with other chemo drugs. Studies have shown that gemcitabine in combination with other chemotherapy medications has a significantly better outcome than gemcitabine on its own. The U.S. Food and Drug Administration approved gemcitabine in 1996 under the brand name Gemzar for treating lung cancer and <a href=\"\/mesothelioma\/\">mesothelioma<\/a>.<\/p>\n<p>Download our <strong>Free Chemotherapy Guide<\/strong> to learn about the top cancer drugs for mesothelioma, what to expect, and how to manage side effects.<\/p>\n<div id=\"28840\" class=\"one-off-28840 widget widget_oscar-vque one-off\" data-vqueid=\"28840\"><style type=\"text\/css\" data-style=\"one-off\">.one-off-28840{margin:60px auto;max-width:335px}.one-off-28840:first-child{margin-top:0}.one-off-28840:last-child{margin-bottom:0}.one-off-28840>a{background:#2F293D;display:block;padding:20px;padding-bottom:35px;border-radius:10px;color:#fff;text-decoration:none}.one-off-28840 img.mobile-only{margin:0 auto 20px;max-width:177px;width:100%}.one-off-28840 img:not(.mobile-only){display:none}.one-off-28840 .vque-content{font-size:16px;text-align:center}.one-off-28840 strong.heading{font-size:24px;display:block;margin:0}.one-off-28840 .subheading{font-size:14px}.one-off-28840 ul{font-size:16px;text-align:left;list-style:none;max-width:265px;line-height:1.4;margin:15px auto 25px}.one-off-28840 ul li{padding-left:28px;margin-bottom:15px}.one-off-28840 ul li:last-child{margin-bottom:0}.one-off-28840 ul li:before{font-family:\"mesohope\"!important;line-height:1;content:\"\\e904\";border:0;position:absolute;left:0;top:0;background:#0FAEBF;width:20px;height:20px;border-radius:20px;line-height:20px;text-align:center;font-size:12px}@media screen and (min-width:768px){.one-off-28840{max-width:620px}.one-off-28840>a{padding:0;background:linear-gradient(90.42deg,#2F293D 51.6%,#4A415F 109.35%)}.one-off-28840>a>div{display:block;display:flex;align-items:end;flex-wrap:wrap;position:relative}.one-off-28840 .vque-content{width:65%;padding:30px;text-align:left}.one-off-28840 img.mobile-only{display:none}.one-off-28840 img:not(.mobile-only){display:block;width:250px;margin-bottom:0;position:absolute;bottom:0;right:0}.one-off-28840 ul{max-width:none}.one-off-28840 ul li{margin-bottom:10px}}<\/style><a href=\"\/chemotherapy-guide\/\" title=\"Free Chemotherapy Guide\u2028for Mesothelioma Patients\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Free Chemotherapy Guide\u2028for Mesothelioma Patients Ad\"><div>\r\n<div>\r\n<div class=\"image-fade\">\r\n<img decoding=\"async\" src=\"\/wp-content\/uploads\/2025\/07\/thank-you-page-chemotherapy-img.png\" alt=\"Chemotherapy Guide Images\" class=\"mobile-only\">\r\n<img decoding=\"async\" src=\"\/wp-content\/uploads\/2025\/07\/chemo-guide-img.png\" alt=\"Chemotherapy Guide Images\">\r\n<\/div>\r\n<\/div>\r\n<div class=\"vque-content\">\r\n<strong class=\"heading\">Free Chemotherapy Guide\u2028for Mesothelioma Patients<\/strong>\r\n<span class=\"subheading\">Written by cancer nurses<\/span>\r\n<ul>\r\n<li>Top chemo drugs explained<\/li>\r\n<li>Preparing for your first session<\/li>\r\n<li>Managing side effects like\u2028nausea & fatigue<\/li>\r\n<\/ul>\r\n<p><strong class=\"button arrow\" title=\"Download It Now\">Download It Now<\/strong><\/p><\/div><\/div><\/a><\/div>\n<h2>How Is Gemcitabine Administered for Mesothelioma?<\/h2>\n<p>Health care professionals administer gemcitabine injections through an intravenous (IV) infusion. This method delivers the <a href=\"\/treatment\/chemotherapy\/drugs\/\">chemo medication<\/a> directly into the patient&#8217;s bloodstream.<\/p>\n<p><strong>Gemcitabine\u2019s<\/strong> <strong>treatment cycle is typically 21 days,<\/strong> with patients receiving the medication <strong>once every three weeks.<\/strong> Mesothelioma patients often receive gemcitabine for several cycles in a row, especially when showing positive changes.<\/p>\n<h2 id=\"work\">How Does Gemcitabine Treat Mesothelioma?<\/h2>\n<p>Gemcitabine is a type of chemotherapy drug known as an antimetabolite. <strong>Antimetabolites block DNA synthesis and slow or stop mesothelioma cancer cells from dividing.<\/strong><\/p>\n<p>Like all chemotherapy drugs, gemcitabine can\u2019t tell the difference between cancer cells and healthy cells. As a result, it attacks cancer cells and healthy cells. During treatment, white blood cells, red blood cells, and platelets are often destroyed.<\/p>\n<p>The good news is that healthy cells usually replenish themselves after a few weeks.<\/p>\n<h2 id=\"drug\">Gemcitabine Drug Combinations<\/h2>\n<p>Gemcitabine is most effective when combined with other <a href=\"\/treatment\/chemotherapy\/drugs\/\">chemotherapy drugs<\/a>. Oncologists often prescribe it because of its <strong>lower toxicity<\/strong> and <strong>milder side effects<\/strong> than other chemo medications.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-18986\" src=\"\/wp-content\/uploads\/2021\/08\/doctor-talking-with-patient-300x166.png\" alt=\"A male doctor speaks with an older male patient\" width=\"300\" height=\"166\" srcset=\"https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2021\/08\/doctor-talking-with-patient-300x166.png 300w, https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2021\/08\/doctor-talking-with-patient.png 670w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>For example, gemcitabine is often chosen as a second line of chemotherapy for patients who can&#8217;t tolerate harsher platinum-based drugs like cisplatin and <a href=\"\/treatment\/chemotherapy\/drugs\/carboplatin\/\">carboplatin<\/a>. For these mesothelioma patients, <strong>gemcitabine and pemetrexed is a common combination for mesothelioma treatment.<\/strong><\/p>\n<p>Gemcitabine chemotherapy is sometimes combined with cisplatin or carboplatin, although this combination isn\u2019t as common.<\/p>\n<p>Gemcitabine and cisplatin can produce high toxicity levels and cause severe side effects. Gemcitabine and carboplatin toxicity levels are still higher than gemcitabine and pemetrexed. As a result, gemcitabine and platinum-based chemotherapy are typically reserved for patients who can tolerate high toxicity but aren\u2019t good candidates for pemetrexed.<\/p>\n<p>Cancer researchers continue researching gemcitabine combinations in laboratory and <a href=\"\/treatment\/clinical-trials\/\">clinical trials for mesothelioma<\/a>. Some of these tests focus on improved chemotherapy combinations, while others are reviewing gemcitabine in combination with smart drugs.<\/p>\n<h2 id=\"clinical\">Current Gemcitabine Clinical Trials<\/h2>\n<p>Early studies of gemcitabine revealed that the drug has minimal impact on mesothelioma when given as the only chemotherapy treatment.<\/p>\n<p>However, gemcitabine is still appreciated by patients and oncologists because of its relatively low toxicity levels. Today, clinical trials for mesothelioma evaluate gemcitabine\u2019s effectiveness when combined with other chemotherapy drugs or <a href=\"\/treatment\/\">mesothelioma treatments<\/a>.<\/p>\n<p>Gemcitabine and <a href=\"\/treatment\/chemotherapy\/drugs\/navelbine\/\">vinorelbine<\/a>, a plant-based chemo drug, are being directly compared to a new experimental immunotherapy drug called pembrolizumab (Keytruda\u00ae).<\/p>\n<p>Pembrolizumab, approved for certain mesothelioma patients in 2020, is potent and blocks the interaction between molecules that cause cancer tumors to grow. The hope is that pembrolizumab will stop growth, force tumors into regression, and ultimately cause the body to reject the cancer.<\/p>\n<p>In another clinical study, researchers are testing transarterial chemoperfusion (killing the blood supply to mesothelioma cells) with gemcitabine, cisplatin, and methotrexate. Additionally, scientists are investigating the use of gemcitabine in combination with <a href=\"\/treatment\/gene-therapy\/\">gene therapy<\/a> to treat patients with pleural mesothelioma.<\/p>\n<p>Italian researchers are studying gemcitabine with or without ramucirumab as a second-line treatment for patients with advanced malignant <a href=\"\/mesothelioma\/pleural\/\">pleural mesothelioma<\/a>. Ramucirumab is a monoclonal antibody that prevents the growth of new blood vessels and limits a tumor&#8217;s oxygen supply.<\/p>\n<p>Phase 2 study results of 161 patients revealed that patients who received both drugs had much better outcomes \u2014 <strong>overall median survival of 13.8 months compared to 7.5 months<\/strong> \u2014 than patients who only received gemcitabine.<\/p>\n<p>Another recent study looked at how effective a drug called gemcitabine is for patients with a type of cancer called malignant pleural mesothelioma. Researchers compared the use of gemcitabine with regular supportive care to see which was better at helping patients.<\/p>\n<p>The study included 64 patients who had responded to an initial round of chemotherapy. Results showed that patients who received gemcitabine could live without their cancer getting worse for longer (around 6.2 months) compared to those who received only supportive care (around 2.8 months). However, the overall length of time that patients lived did not differ significantly between the two groups. In conclusion, gemcitabine can help slow cancer progression but does not significantly increase patients&#8217; lives with malignant pleural mesothelioma.<\/p>\n<p>Many mesothelioma patients have been able to live for a decade or more with the help of cutting-edge treatments. Read about the treatments that helped 7 patients live longer and become survivors in your <a href=\"\/survivors-guide\/\"><strong>Free Mesothelioma Survivors Guide<\/strong><\/a>.<\/p>\n<div data-vqueid=\"21915\" class=\"widget widget_oscar-vque light-blue has-img\"><style type=\"text\/css\" data-style=\"default\">.widget_oscar-vque.light-blue{margin:60px auto;line-height:26px;max-width:337px}.widget_oscar-vque.light-blue a{display:block;background:#EDF8F9;border-left:4px solid #0FAEBF;border-radius:0px 8px 8px 0px;padding:25px;color:#100134;text-decoration:none;font-size:16px;text-align:center}.widget_oscar-vque.light-blue .image-wrap{max-width:210px;margin:0 auto 15px}.widget_oscar-vque.light-blue .heading{display:block;font-size:22px;margin-bottom:10px}.widget_oscar-vque.light-blue ul{max-width:245px;list-style:none;margin:0 auto 22px;text-align:left}.widget_oscar-vque.light-blue ul li{margin:0 0 5px;position:relative;padding-left:26px}.widget_oscar-vque.light-blue ul li:before{font-family:\"mesohope\" !important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;content:\"\\e904\";background:#0FAEBF;width:20px;height:20px;display:block;position:absolute;left:0;top:2px;border-radius:20px;color:#fff;font-size:10px;text-align:center;line-height:20px}@media screen and (min-width: 768px){.widget_oscar-vque.light-blue{max-width:620px}.widget_oscar-vque.light-blue a{padding:0}.widget_oscar-vque.light-blue a>div{display:block;display:flex;flex-wrap:wrap;overflow:hidden;flex-direction:row-reverse}.widget_oscar-vque.light-blue .image-wrap{float:right;align-self:flex-end;padding:0 3%;width:47%;margin:0;max-width:none}.widget_oscar-vque.light-blue .vque-content{float:left;text-align:left;padding:30px;width:53%}.widget_oscar-vque.light-blue .heading{font-size:24px;line-height:1;margin-bottom:13px}.widget_oscar-vque.light-blue ul{margin:0 0 22px}}<\/style><a href=\"\/survivors-guide\/\" title=\"Get Your Free Survivors Guide\" class=\"cte\" data-ce-category=\"In-Content Ads\" data-ce-label=\"Survivors List Ad\" data-desktop-image=\"https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2023\/07\/mh-survivor-guide-cover.png\"><div><div class=\"image-wrap\"><img loading=\"lazy\" decoding=\"async\" width=\"431\" height=\"402\" src=\"https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2023\/07\/mh-survivor-guide-cover.png\" class=\"attachment-Medium size-Medium wp-post-image\" alt=\"Mesothelioma Survivors Guide\" srcset=\"https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2023\/07\/mh-survivor-guide-cover.png 431w, https:\/\/www.mesotheliomahope.com\/wp-content\/uploads\/2023\/07\/mh-survivor-guide-cover-300x280.png 300w\" sizes=\"(max-width: 431px) 100vw, 431px\" \/><\/div><div class=\"vque-content\"><strong class=\"heading\">Get Your Free Survivors Guide<\/strong><ul>\n<li>Survivors who beat the odds<\/li>\n<li>Tips for fighting mesothelioma<\/li>\n<li>Navigating life after treatment<\/li>\n<\/ul>\n<p><strong class=\"button arrow\" title=\"Get It Shipped Overnight\">Get It Shipped Overnight<\/strong><\/p><\/div><\/div><\/a><\/div>\n<h3>HIPEC Database<\/h3>\n<p>Mesothelioma specialists worldwide are also creating a <strong>database of patients who have received gemcitabine or other chemotherapy medications during Hyperthermic Intraperitoneal Chemotherapy (HIPEC).<\/strong> HIPEC, or heated chemotherapy, is often used to treat patients with <a href=\"\/mesothelioma\/peritoneal\/\">peritoneal mesothelioma<\/a> as part of a two-part procedure known as <a href=\"\/treatment\/surgery\/cytoreduction-hipec\/\">cytoreduction surgery with HIPEC<\/a>.<\/p>\n<p>The international initiative gathers data and outcomes from 1,000 mesothelioma patients to help determine whether gemcitabine should be used in the HIPEC procedure. Thirteen countries participate in the collaborative project, including Australia, Denmark, Germany, and Russia.<\/p>\n<h2 id=\"side\">Gemcitabine Side Effects<\/h2>\n<p>Patients receiving gemcitabine can expect common <a href=\"\/treatment\/side-effects\/\">side effects,<\/a> including flu-like symptoms such as chills, fever, and fatigue.<\/p>\n<p><strong>Other gemcitabine side effects include:<\/strong><\/p>\n<\/p>\n<ul class=\"columns-2\">\n<li>Anemia<\/li>\n<li>Constipation<\/li>\n<li>Hair loss<\/li>\n<li>Loss of appetite<\/li>\n<li>Low blood cells<\/li>\n<li>Nausea<\/li>\n<li>Skin rash<\/li>\n<li>Vomiting<\/li>\n<\/ul>\n<p>\n<p>Although gemcitabine side effects are rarely life-threatening, some patients may have an allergic reaction. <strong>Patients should report any adverse effects to their oncology team. <\/strong><\/p>\n<p>Most gemcitabine patients will have low blood counts and are at a greater risk of anemia and infection at this time. <strong>Blood levels typically reach their lowest point 10-14 days after gemcitabine is administered.<\/strong> Blood levels usually return to normal 21 days after treatment.<\/p>\n<p>Fortunately, all gemcitabine side effects follow predictable patterns and don\u2019t tend to last long after chemotherapy has stopped. Mesothelioma patients can expect the negative side effects of gemcitabine to subside after their treatment ends.<\/p>\n<p>If you\u2019ve been diagnosed with mesothelioma, you may be a candidate for chemotherapy treatment.<\/p>\n<p>Learn about the treatments that helped 7 mesothelioma patients outlive their diagnosis and become mesothelioma survivors \u2014 get your <strong><a href=\"\/survivors-guide\/\">Free Mesothelioma Survivors Guide<\/a><\/strong>.<\/p>\n<div class=\"faq-wrap\"><h2 class=\"faq-wrap-heading\">Gemcitabine FAQS<\/h2><div class=\"faq\" data-faq=\"1\"><h3 class=\"faq-heading\">What kind of chemo is gemcitabine?<\/h3><div><p>Gemcitabine, known by the brand name Gemzar, is in a type of chemotherapy drug that is considered an antimetabolite. Antimetabolites work by interfering with DNA synthesis and slowing or halting the growth of cancer cells.<\/p>\n<p>Gemcitabine treats many types of cancer, including mesothelioma, breast cancer, ovarian cancer, and bladder cancer. It is usually used in combination with other chemo drugs.<\/p>\n<\/div><\/div><div class=\"faq\" data-faq=\"2\"><h3 class=\"faq-heading\">What is the success rate of gemcitabine?<\/h3><div><p>Researchers are currently studying the success rate of gemcitabine either alone or with other chemotherapy drugs or therapies in patients with mesothelioma.<\/p>\n<p>In a recent clinical study of 161 patients, Italian researchers looked at the use of gemcitabine with or without a <a href=\"\/treatment\/targeted-therapies\/monoclonal-antibodies\/\">monoclonal antibody<\/a> called ramucirumab as second-line treatment for advanced malignant pleural mesothelioma. Ramucirumab blocks the growth of new blood vessels, which limits the supply of oxygen to the tumor.<\/p>\n<p>The researchers found that the patients who received both drugs had much better outcomes \u2014 <strong>overall median survival of 13.8 months compared to 7.5 months<\/strong> \u2014 than the patients who only received gemcitabine.<\/p>\n<\/div><\/div><script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\",\"@type\": \"FAQPage\",\"mainEntity\": [{\"@type\": \"Question\",\"name\": \"What kind of chemo is gemcitabine?\",\"acceptedAnswer\":{\"@type\": \"Answer\",\"text\": \"&lt;p&gt;Gemcitabine, known by the brand name Gemzar, is in a type of chemotherapy drug that is considered an antimetabolite. Antimetabolites work by interfering with DNA synthesis and slowing or halting the growth of cancer cells.&lt;\/p&gt;\n&lt;p&gt;Gemcitabine treats many types of cancer, including mesothelioma, breast cancer, ovarian cancer, and bladder cancer. 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Ramucirumab blocks the growth of new blood vessels, which limits the supply of oxygen to the tumor.&lt;\/p&gt;\n&lt;p&gt;The researchers found that the patients who received both drugs had much better outcomes \u2014 &lt;strong&gt;overall median survival of 13.8 months compared to 7.5 months&lt;\/strong&gt; \u2014 than the patients who only received gemcitabine.&lt;\/p&gt;\n\"}}]}<\/script><style type=\"text\/css\">.faq-wrap{background:#E4F4F6;padding:20px 15px;margin:40px -15px}.faq-wrap:first-child{margin-top:0}.faq-wrap:last-child{margin-bottom:0}.faq-wrap .faq{background:#fff;padding:15px;border-radius:10px;box-shadow:0px 20px 20px rgba(0,0,0,0.03);margin:15px 0 0 0}.faq-wrap .faq:first-child{margin-top:0}.faq-wrap .faq .faq-heading{color:#100134;font-size:21px;margin-bottom:15px}.faq-wrap .faq p{margin-bottom:20px;line-height:1.5}.faq-wrap .faq p:last-child{margin-bottom:0}.faq-wrap .faq .learn-more{color:#248AFF;display:block;padding-right:17px;text-align:right;position:relative;line-height:1}.faq-wrap .faq .learn-more:visited{color:#248AFF}.faq-wrap .faq .learn-more:visited:hover,.faq-wrap .faq .learn-more:hover{color:#34d}.faq-wrap .faq .learn-more:after{font-family:\"mesohope\" !important;speak:none;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;line-height:1;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;content:\"\\e905\";position:absolute;right:0;top:3px}h2.faq-wrap-heading{margin-bottom:25px}@media screen and (min-width: 768px){.faq-wrap{padding:25px 15px}}@media screen and (min-width: 1024px){.faq-wrap{border-radius:10px;margin-left:auto;margin-right:auto;padding:25px}.faq-wrap .faq{padding:25px}.faq-heading{font-size:24px}}<\/style><\/div>\n","protected":false},"excerpt":{"rendered":"<p>What Is Gemcitabine? For many mesothelioma patients, the most effective chemotherapy combination is the platinum-based chemo drug cisplatin and pemetrexed (Alimta). In most cases, gemcitabine chemotherapy is only used when a patient can\u2019t tolerate cisplatin, has an allergy, or there\u2019s some other reason the cisplatin and pemetrexed combination shouldn\u2019t be used. Gemcitabine is not as&hellip;<\/p>\n","protected":false},"author":49,"featured_media":17812,"parent":830,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-834","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/comments?post=834"}],"version-history":[{"count":0,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/834\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/pages\/830"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media\/17812"}],"wp:attachment":[{"href":"https:\/\/www.mesotheliomahope.com\/wp-json\/wp\/v2\/media?parent=834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}